Anti‐idiotypic IgM Antibodies to Anti‐HLA Class I Antibodies in Habitual Abortion

ESTHER BEHAR, HOWARD CARP, AVI LIVNEH, EPHRAIM GAZIT*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

ABSTRACT: In order to investigate the role of the idiotypic network in miscarriages, sera from 28 habitually aborting women undergoing paternal leukocyte immunization were studied for the presence of HLA antibodies and related anti‐idiotypes. Sixty‐eight percent of sera from preimmunized patients which did not contain anti‐lymphocyte antibodies inhibited the activity of antibodies to the HLA class I antigens expressed by the spouse. This inhibitory activity could be assigned to IgM antibodies, which cross‐inhibit antibodies of similar specificity. This suggests that they are antiidiotypes for the binding site of HLA antibodies. Immune sera of successfully treated patients exhibited both cytotoxic IgG anti‐HLA antibodies and inhibitory IgM anti‐idiotypic antibodies. A possible role for an intact idiotypic network in maintaining pregnancy is suggested. 1991 Munksgaard

Original languageEnglish
Pages (from-to)143-146
Number of pages4
JournalAmerican Journal of Reproductive Immunology
Volume26
Issue number4
DOIs
StatePublished - Dec 1991

Keywords

  • Habitual abortion
  • anti‐idiotypes
  • paternal immunization

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