TY - JOUR
T1 - Antihemorrhagic factors from the blood serum of the western diamondback rattlesnake Crotalus atrox
AU - Weissenberg, Sarah
AU - Ovadia, Michael
AU - Fleminger, Gideon
AU - Kochva, Elazar
N1 - Funding Information:
Acknowledgements-We thank Prof. A. HnouH, Prof. D. M~ctuersoN and Prof. A. Hoct~t~rr for their advice; Mrs S. K~rr~+etox, Mr D. Gowew and Mrs O. B~ctutt for their assistance and Dr J. KILetoN for the gift of C. atrox venom. This work was supported in part by a grant of the Basic Research Foundation of Tel-Aviv University (M .O.) and by We Ross and Nox~tert L©r.REte chair in experimental biology (E .K.).
PY - 1991
Y1 - 1991
N2 - Several antihemorrhagic factors isolated from C. atrox serum are glycoproteins with mol. wt ranging from 65,000 to 80,000. The antihemorrhagic activity of these factors was stable at a pH range of 1.3-11.5 and at temperatures up to 85°C, for 30 min. The isolated antihemorrhagins also neutralized the proteolytic activity of C. atrox venom, as tested with azocollagen and gelatin, and formed a complex with hemorrhagic toxin e isolated from the same venom. The neutralization capacity of the isolated antihemorrhagins was six times as high as the commercial polyvalent antivenom produced for clinical use.
AB - Several antihemorrhagic factors isolated from C. atrox serum are glycoproteins with mol. wt ranging from 65,000 to 80,000. The antihemorrhagic activity of these factors was stable at a pH range of 1.3-11.5 and at temperatures up to 85°C, for 30 min. The isolated antihemorrhagins also neutralized the proteolytic activity of C. atrox venom, as tested with azocollagen and gelatin, and formed a complex with hemorrhagic toxin e isolated from the same venom. The neutralization capacity of the isolated antihemorrhagins was six times as high as the commercial polyvalent antivenom produced for clinical use.
UR - https://www.scopus.com/pages/publications/0025737659
U2 - 10.1016/0041-0101(91)90217-F
DO - 10.1016/0041-0101(91)90217-F
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AN - SCOPUS:0025737659
SN - 0041-0101
VL - 29
SP - 807
EP - 818
JO - Toxicon
JF - Toxicon
IS - 7
ER -