Antiganglioside Antibodies Inhibit Neuritic Outgrowth from Regenerating Goldfish Retinal Explants

Nurit Spirman, Ben‐Ami ‐A Sela, Michal Schwartz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Abstract: Antibodies elicited in rabbits against bovine brain gangliosides were applied to regenerating retinal explants to examine the role of gangliosides in the trophic effect responsible for the induction of outgrowth. The results indicate that antibodies specific to gangliosides block the neuritic outgrowth from the regenerating retinal explants. It is inferred that gangliosides function as receptors on the cell surface of the retinal explants that interact with the trophic substances inducing the outgrowth. The relevance of gangliosides to the mechanism of regeneration and development induced by trophic factors is discussed.

Original languageEnglish
Pages (from-to)874-877
Number of pages4
JournalJournal of Neurochemistry
Volume39
Issue number3
DOIs
StatePublished - Sep 1982
Externally publishedYes

Keywords

  • Antibodies
  • Gangliosides
  • In vitro‐Goldfish
  • Regeneration

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