@article{81ad97cca9bf4d2295f615bea272a6ca,
title = "Antifreeze protein suppresses spontaneous neural activity and protects neurons from hypothermia/re-warming injury",
abstract = "Antifreeze proteins (AFP) are associated with protection from freezing. We measured the effect of type I antifreeze protein on spontaneous bursting of mixed neuronal/glial cultures using a multi-electrode array culture system. Antifreeze protein (10. mg/ml) reversibly depressed bursting activity without inhibiting mitochondrial oxidative capacity. The effect of antifreeze protein on cold/re-warming injury was investigated in rat hippocampal slice cultures. Compared to bovine serum albumin at a similar concentration, antifreeze protein protected hippocampal neurons from 8. h of profound hypothermia at (4°C) followed by re-warming. The protection observed is believed to be associated with the inhibitory effect of antifreeze protein.",
keywords = "Antifreeze proteins, Hypothermia, Ion channels, Neural network dynamics, Neurons, Neuroprotection",
author = "Liel Rubinsky and Nadav Raichman and Jacob Lavee and Hanan Frenk and Eshel Ben-Jacob and Bickler, {Philip E.}",
year = "2010",
month = jul,
doi = "10.1016/j.neures.2010.04.004",
language = "אנגלית",
volume = "67",
pages = "256--259",
journal = "Neuroscience Research",
issn = "0168-0102",
publisher = "Elsevier Ireland Ltd",
number = "3",
}