Antidepressant associated mania: A study of anxiety disorders patients

D. Levy, R. Kimhi*, Y. Barak, A. Aviv, A. Elizur

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Antidepressants are related to the emergence of manic and hypomanic episodes in mood disorder patients. This study examined whether antidepressant-associated manic states are also present in anxiety disorderr patients, so that this phenomenon may be defined as a side-effect. A total of 167 consecutive patients at a specialized outpatient clinic, suffering from anxiety disorders and treated by antidepressants, were assessed in a blind, retrospective chart review. Five patients (2.99%) were identified as having suffered an episode of antidepressant-associated mania within 3 months of initiation of treatment. All were females and all had an axis II diagnosis of a cluster B personality disorder. Antidepressant-associated mania appears to be related to risk factors such as personality disorder, even in non-mood disorder patients, tentatively suggesting that it is not simply an adverse event but rather a reflection of an underlying psychopathology.

Original languageEnglish
Pages (from-to)243-246
Number of pages4
Issue number3
StatePublished - 1998


  • Antidepressant-associated mania
  • Anxiety disorder


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