TY - JOUR
T1 - Anticonflict action of sodium valproate. Interaction with convulsant benzodiazepine (Ro 5-3663) and imidazodiazepine (Ro 15-1788)
AU - Myslobodsky, M.
AU - Feldon, J.
AU - Lerner, T.
PY - 1983
Y1 - 1983
N2 - The possibility that Ro 15-1788, a specific benzodiazepine antagonist would reverse the anxiolytic effect of VPA (200 mg/kg) in the Geller-Seifter paradigm was tested, using male albino rats. VPA (200 mg/kg) induced disinhibition which was antagonized by a convulsant benzodiazepine, Ro 5-3663 (1 mg/kg), but not by imidazobenzodiazepine, Ro 15-1788 at doses of 10 mg/kg, or 30 mg/kg. However, Ro 15-1788 (30 mg/kg) did have a short lasting antagonistic effect on VPA when tested in a “condensed” form (see text) of the conflict test. The nature of the anticonflict potency of VPA is discussed.
AB - The possibility that Ro 15-1788, a specific benzodiazepine antagonist would reverse the anxiolytic effect of VPA (200 mg/kg) in the Geller-Seifter paradigm was tested, using male albino rats. VPA (200 mg/kg) induced disinhibition which was antagonized by a convulsant benzodiazepine, Ro 5-3663 (1 mg/kg), but not by imidazobenzodiazepine, Ro 15-1788 at doses of 10 mg/kg, or 30 mg/kg. However, Ro 15-1788 (30 mg/kg) did have a short lasting antagonistic effect on VPA when tested in a “condensed” form (see text) of the conflict test. The nature of the anticonflict potency of VPA is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0020598368&partnerID=8YFLogxK
U2 - 10.1016/S0024-3205(83)80003-4
DO - 10.1016/S0024-3205(83)80003-4
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AN - SCOPUS:0020598368
SN - 0024-3205
VL - 33
SP - 317
EP - 321
JO - Life Sciences
JF - Life Sciences
IS - 4
ER -