Anticollagen Antibodies

Oren Pasvolsky, Rina Ulmansky, Yaakov Naparstek, Alon Y. Hershko

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Collagen is a triple-helical molecule, which functions as the major scaffold protein in tissues and participates in cell–matrix interactions. Its deposition in the extracellular compartment renders it an immunogen and a target for attack by autoantibodies in susceptible individuals. Several types of collagens have been described as the target of autoantibodies in autoimmune diseases, and the clinical features of the ensuing disease reflect the organ location of the specific collagen. Collagens that are implicated in autoimmunity include types I, II, III, V (e.g., adult and juvenile rheumatoid arthritis (RA)), type IV (Goodpasture syndrome), types VII and XVII (immunobullous diseases), and type XIII (Graves’ disease). In some cases, the causative role of antibodies has been clearly established in animal models. In everyday clinical practice, identification of anticollagen antibodies in the appropriate setting may help the clinician in establishing an accurate diagnosis and in predicting the prognosis.

Original languageEnglish
Title of host publicationAutoantibodies, Third Edition
PublisherElsevier
Pages717-722
Number of pages6
ISBN (Electronic)9780444563781
ISBN (Print)9780444593771
DOIs
StatePublished - 1 Jan 2014

Keywords

  • Autoantibodies
  • Goodpasture syndrome
  • Graves’ disease
  • autoimmunity
  • collagen
  • immunobullous disorders
  • rheumatoid arthritis

Fingerprint

Dive into the research topics of 'Anticollagen Antibodies'. Together they form a unique fingerprint.

Cite this