Anticodon nucleases

Gabriel Kaufmann*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

124 Scopus citations


A tRNA(Lys)-specific anticodon nuclease is kept in a latent form in a rare Escherichia coli strain, complexed with a DNA restriction enzyme. A phage T4 inhibitor of DNA restriction activates anticodon nuclease, but other T4 proteins restore tRNA(Lys). Detection of a homologous system in Neisseria and a different anticodon nuclease in colicin E5 suggest ubiquity and diversity of such tRNA toxins. Analysis of these systems could reveal novel RNA recognition and cleavage mechanisms.

Original languageEnglish
Pages (from-to)70-74
Number of pages5
JournalTrends in Biochemical Sciences
Issue number2
StatePublished - 1 Feb 2000


FundersFunder number
Israeli Academy of Sciences and Israeli Ministry of Health
Brain Science Foundation


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