TY - JOUR
T1 - Antibodies to ureaplasma urealyticum in women with intraamniotic infection and adverse pregnancy outcome
AU - Horowitz, Shulamith
AU - Mazor, Moshe
AU - Horowitz, Jacob
AU - Porath, Avl
AU - Glezerman, Marek
PY - 1995/2
Y1 - 1995/2
N2 - Objective. To determine the association between antibody response to Ureaplasma urealyticum and pregnancy outcome in women with ureaplasmal invasion of the amniotic cavity. Methods. A cross section study was performed in our high risk pregnancy unit. Three groups of pregnant women were identified: 1) 271 women at the midtrimester of pregnancy (16–20 weeks), who underwent transabdominal amniocentesis for genetic indications 2) 161 consecutive women admitted with preterm labor and intact membranes. 3) 118 consecutive patients with preterm premature rupture of membranes. Amniotic fluids were cultured for Ureaplasma urealyticum, Mycoplasma hominis and also for other aerobic and anaerobic bacteria. Serum antibodies to Uu were measured by a specific enzyme‐linked‐immunosorbent‐assay. Results. The prevalence of positive AF cultures with Uu in the 3 study groups was 2.9%, 4.3% and 17.8%, and the prevalence of antibodies to Uu in the AF‐colonized patients was 50%, 86% and 57%, respectively. Adverse pregnancy outcome (preterm birth, low birth weight or fetal death) among all AF colonized women, was significantly higher in patients with antibodies to Uu than in those without antibodies; preterm delivery 90% vs. 43%, and low birth weight infants or fetal death 85% vs. 28%, p=0.006 and 0.001 respectively. Conclusion. Women with intraamniotic infection with Uu and elevated levels of antibodies to Uu, had a higher rate of preterm delivery, and low birthweight infantdfetal death than those without antibody to Uu. 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
AB - Objective. To determine the association between antibody response to Ureaplasma urealyticum and pregnancy outcome in women with ureaplasmal invasion of the amniotic cavity. Methods. A cross section study was performed in our high risk pregnancy unit. Three groups of pregnant women were identified: 1) 271 women at the midtrimester of pregnancy (16–20 weeks), who underwent transabdominal amniocentesis for genetic indications 2) 161 consecutive women admitted with preterm labor and intact membranes. 3) 118 consecutive patients with preterm premature rupture of membranes. Amniotic fluids were cultured for Ureaplasma urealyticum, Mycoplasma hominis and also for other aerobic and anaerobic bacteria. Serum antibodies to Uu were measured by a specific enzyme‐linked‐immunosorbent‐assay. Results. The prevalence of positive AF cultures with Uu in the 3 study groups was 2.9%, 4.3% and 17.8%, and the prevalence of antibodies to Uu in the AF‐colonized patients was 50%, 86% and 57%, respectively. Adverse pregnancy outcome (preterm birth, low birth weight or fetal death) among all AF colonized women, was significantly higher in patients with antibodies to Uu than in those without antibodies; preterm delivery 90% vs. 43%, and low birth weight infants or fetal death 85% vs. 28%, p=0.006 and 0.001 respectively. Conclusion. Women with intraamniotic infection with Uu and elevated levels of antibodies to Uu, had a higher rate of preterm delivery, and low birthweight infantdfetal death than those without antibody to Uu. 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
KW - Ureaplasma urealyticum
KW - antibodies to ureaplasmas
KW - intraamniotic infection
KW - pregnancy outcome
UR - http://www.scopus.com/inward/record.url?scp=0028930530&partnerID=8YFLogxK
U2 - 10.3109/00016349509008922
DO - 10.3109/00016349509008922
M3 - מאמר
C2 - 7900509
AN - SCOPUS:0028930530
VL - 74
SP - 132
EP - 136
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
SN - 0001-6349
IS - 2
ER -