@article{3409c3475ceb4fd4939e773ae22a1547,
title = "Antibodies to placental immunoregulatory ferritin with transfer of polyclonal lymphocytes arrest MCF-7 human breast cancer growth in a nude mouse model",
abstract = "The recently cloned human gene named {"}placental immunoregulatory ferritin{"} (PLIF ) is a pregnancy-related immunomodulator. Recombinant PLIF and its bioactive domain C48 are immune-suppressive and induce pronounced IL-10 production by immune cells. PLIF is expressed in the placenta and breast cancer cells. Blocking PLIF in pregnant mice by anti-C48 antibodies inhibited placental and fetal growth and modulated the cytokine network. It has been revealed that anti-C48 treatment inhibited MCF-7 tumor growth in nude mice. However, this significant effectwas observed only in those transfused with human peripheral blood mononuclear cells. Blocking PLIF in tumor-engrafted human immune cell transfusedmice resulted inmassive infiltration of human CD45+ cells (mainly CD8+ T cells), both intratumorally and in the tumor periphery, and a significant number of caspase-3+ cells. In vitro, anti-C48 treatment of MCF-7 tumor cells cocultured with human lymphocytes induced a significant increase in interferon-γ secretion. We conclude that blocking PLIF inhibits breast cancer growth, possibly by an effect on the cytokine network in immune cells and on breakdown of immunosuppression.",
keywords = "Antibody, Breast cancer, Gene, Immunomodulator, Immunotherapy",
author = "Marisa Halpern and Zahalka, {Muayad A.} and Leonid Traub and Chaya Moroz",
note = "Funding Information: The authors thank the Dvorson Fund for financial support.",
year = "2007",
month = jun,
doi = "10.1593/neo.07259",
language = "אנגלית",
volume = "9",
pages = "487--494",
journal = "Neoplasia",
issn = "1522-8002",
publisher = "Elsevier Inc.",
number = "6",
}