Antibodies to Laminin

Rina Ulmansky; Alon Y. Hershko; Yaakov Naparstek

doi:10.1016/B978-0-444-56378-1.00079-4

Antibodies to Laminin

Rina Ulmansky, Alon Y. Hershko, Yaakov Naparstek

Internal Medicine

Hadassah University Medical Centre

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Laminins are major components of the basement membrane, forming essential contacts with cells and other components of the basal lamina, thereby inducing dynamic interactions in the tissue through intracellular signaling, promoting/regulating cell adhesion, spreading, and differentiation. Autoantibodies to laminin have been found in autoimmune disorders such as pemphigoids, rheumatic fever, systemic lupus erythematosus (SLE), and cutaneous lupus erythematosus as well as in Chagas disease and in women with recurrent abortions and/or infertility. The antibodies bind mainly the LG domain of the α chain of laminin, and in some cases they seem to appear as a consequence of antigenic mimicry. Their pathogenic role and diagnostic value are currently being investigated.

Original language	English
Title of host publication	Autoantibodies, Third Edition
Publisher	Elsevier
Pages	671-680
Number of pages	10
ISBN (Electronic)	9780444563781
ISBN (Print)	9780444593771
DOIs	https://doi.org/10.1016/B978-0-444-56378-1.00079-4
State	Published - 1 Jan 2014

Keywords

Basement membrane
SLE
laminin
pemphigoid
spontaneous abortions

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10.1016/B978-0-444-56378-1.00079-4

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AB - Laminins are major components of the basement membrane, forming essential contacts with cells and other components of the basal lamina, thereby inducing dynamic interactions in the tissue through intracellular signaling, promoting/regulating cell adhesion, spreading, and differentiation. Autoantibodies to laminin have been found in autoimmune disorders such as pemphigoids, rheumatic fever, systemic lupus erythematosus (SLE), and cutaneous lupus erythematosus as well as in Chagas disease and in women with recurrent abortions and/or infertility. The antibodies bind mainly the LG domain of the α chain of laminin, and in some cases they seem to appear as a consequence of antigenic mimicry. Their pathogenic role and diagnostic value are currently being investigated.

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Antibodies to Laminin

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