TY - JOUR
T1 - Antibodies to brain antigens following stroke
AU - Bornstein, N. M.
AU - Aronovich, B.
AU - Korczyn, A. D.
AU - Shavit, S.
AU - Michaelson, D. M.
AU - Chapman, Joab
PY - 2001/2/27
Y1 - 2001/2/27
N2 - Cerebral necrosis following stroke exposes brain antigens to the immune system, potentially initiating an antibody response. The authors measured levels of antibodies to specific neuronal antigens, neurofilaments (NF), and a ubiquitous antigen, cardiolipin (CL), in 45 patients following an acute first-ever stroke, within 48 hours, and 1, 3, and 6 months later. The mean levels of anti-NF antibodies were elevated compared with baseline at 1, 3, and 6, months (p = 0.012, 0.002, and 0.003 by paired t-test). Anti-CL levels did not change significantly.
AB - Cerebral necrosis following stroke exposes brain antigens to the immune system, potentially initiating an antibody response. The authors measured levels of antibodies to specific neuronal antigens, neurofilaments (NF), and a ubiquitous antigen, cardiolipin (CL), in 45 patients following an acute first-ever stroke, within 48 hours, and 1, 3, and 6 months later. The mean levels of anti-NF antibodies were elevated compared with baseline at 1, 3, and 6, months (p = 0.012, 0.002, and 0.003 by paired t-test). Anti-CL levels did not change significantly.
UR - http://www.scopus.com/inward/record.url?scp=0035957077&partnerID=8YFLogxK
U2 - 10.1212/WNL.56.4.529
DO - 10.1212/WNL.56.4.529
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AN - SCOPUS:0035957077
SN - 0028-3878
VL - 56
SP - 529
EP - 530
JO - Neurology
JF - Neurology
IS - 4
ER -
