TY - JOUR
T1 - Antibodies to Bordetella pertussis adenylate cyclase are produced in man during pertussis infection and after vaccination
AU - Farfel, Z.
AU - Konen, S.
AU - Wiertz, E.
AU - Klapmuts, R.
AU - Addy, P. A.K.
AU - Hanski, E.
PY - 1990
Y1 - 1990
N2 - Bordetella pertussis produces several potential virulence factors. One of these is an adenylate cyclase which penetrates eukaryotic cells, is activated by calmodulin and generates high levels of intracellular cAMP. We have found that pertussis infection in man leads to production of high titres (2000-8000) of anti-B. pertussis adenylate cyclase antibodies. Such antibodies also are produced after pertussis vaccination. They persist into adulthood, cross the placenta and disappear a few months after birth. The anti-adenylate cyclase antibodies found in human serum during pertussis infection do not neutralise the catalytic and penetrative activities of the enzyme.
AB - Bordetella pertussis produces several potential virulence factors. One of these is an adenylate cyclase which penetrates eukaryotic cells, is activated by calmodulin and generates high levels of intracellular cAMP. We have found that pertussis infection in man leads to production of high titres (2000-8000) of anti-B. pertussis adenylate cyclase antibodies. Such antibodies also are produced after pertussis vaccination. They persist into adulthood, cross the placenta and disappear a few months after birth. The anti-adenylate cyclase antibodies found in human serum during pertussis infection do not neutralise the catalytic and penetrative activities of the enzyme.
UR - http://www.scopus.com/inward/record.url?scp=0025277227&partnerID=8YFLogxK
U2 - 10.1099/00222615-32-3-173
DO - 10.1099/00222615-32-3-173
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AN - SCOPUS:0025277227
SN - 0022-2615
VL - 32
SP - 173
EP - 177
JO - Journal of Medical Microbiology
JF - Journal of Medical Microbiology
IS - 3
ER -
