@article{4c8047c48ffa47d6a4df6dcdc1773200,
title = "Antibodies against transforming growth factor-β1 suppress intimal hyperplasia in a rat model",
abstract = "Intimal hyperplasia is induced by therapeutic vascular interventions and often results in clinically important narrowing of the vascular lumen. Examination of the role of TGF-β1 in a rat carotid artery injury model confirmed the presence of a previously reported increase in TGF-β1 mRNA in the media of injured arteries. Administration of neutralizing anti-TGF-β1 antibodies significantly (P < 0.05) reduced the size of the intimal lesions that developed after carotid balloon injury. A control antibody had no effect. The intimal/medial area ratio was also reduced in the anti-TGF-β1 group relative to controls (P < 0.01). Immunohistochemical staining showed that two TGF-β1-induced extracellular matrix components, EDA + fibronectin and versican, were greatly increased in the untreated neointimal lesions, but were almost completely absent from the lesions of the anti-TGF-β1-treated animals. We conclude that TGF-β1 is causally involved in the development of intimal hyperplasia, and that anti-TGF-β1 agents may be useful in achieving at least partial control of this condition.",
keywords = "anti- transforming growth factor-β, arterial injury, extracellular matrix, intimal hyperplasia, transforming growth factor-β",
author = "Wolf, {Yehuda G.} and Rasmussen, {Lars M.} and Erkki Ruoslahti",
year = "1994",
month = mar,
doi = "10.1172/JCI117070",
language = "אנגלית",
volume = "93",
pages = "1172--1178",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "3",
}