Antibiotic treatment in acute otitis media: 'In vivo' demonstration of antibacterial activity

Ron Dagan; Dan M. Fliss; Eugene Leibovitz; Oren Abramson; David Greenberg; Ruth Lang; Swan Goshen; Pablo Yagupsky; Alberto Leiberman

doi:10.1016/s1198-743x(14)64952-1

Antibiotic treatment in acute otitis media: 'In vivo' demonstration of antibacterial activity

Ron Dagan, Dan M. Fliss, Eugene Leibovitz, Oren Abramson, David Greenberg, Ruth Lang, Swan Goshen, Pablo Yagupsky, Alberto Leiberman

Research output: Contribution to journal › Review article › peer-review

Abstract

The ultimate goal in antibiotic treatment of acute otitis media (AOM) is eradication of the pathogens from the middle ear fluid (MEF). To test the ability of an antibiotic to achieve this goal, the best available method is to obtain MEF by aspiration before initiating antibiotics and to repeat this procedure during treatment, a method which was termed the 'in vivo sensitivity test'. This advantageous method is difficult to perform and thus only a few groups were able to conduct such large-scale studies. The available information is discussed in the present manuscript, as well as some preliminary results suggesting that oral β-lactam antibiotics may not be the ideal drugs to date, due to the emergence of resistant pneumococci.

Original language	English
Pages (from-to)	3S43-3S48
Journal	Clinical Microbiology and Infection
Volume	3
Issue number	SUPPL. 3
DOIs	https://doi.org/10.1016/s1198-743x(14)64952-1
State	Published - Jun 1997
Externally published	Yes

Keywords

Antibiotic treatment
Bacteriology
Otitis media

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/s1198-743x(14)64952-1

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title = "Antibiotic treatment in acute otitis media: 'In vivo' demonstration of antibacterial activity",

abstract = "The ultimate goal in antibiotic treatment of acute otitis media (AOM) is eradication of the pathogens from the middle ear fluid (MEF). To test the ability of an antibiotic to achieve this goal, the best available method is to obtain MEF by aspiration before initiating antibiotics and to repeat this procedure during treatment, a method which was termed the 'in vivo sensitivity test'. This advantageous method is difficult to perform and thus only a few groups were able to conduct such large-scale studies. The available information is discussed in the present manuscript, as well as some preliminary results suggesting that oral β-lactam antibiotics may not be the ideal drugs to date, due to the emergence of resistant pneumococci.",

keywords = "Antibiotic treatment, Bacteriology, Otitis media",

author = "Ron Dagan and Fliss, {Dan M.} and Eugene Leibovitz and Oren Abramson and David Greenberg and Ruth Lang and Swan Goshen and Pablo Yagupsky and Alberto Leiberman",

year = "1997",

month = jun,

doi = "10.1016/s1198-743x(14)64952-1",

language = "אנגלית",

volume = "3",

pages = "3S43--3S48",

journal = "Clinical Microbiology and Infection",

issn = "1198-743X",

publisher = "Elsevier Ltd.",

number = "SUPPL. 3",

}

Antibiotic treatment in acute otitis media : 'In vivo' demonstration of antibacterial activity. / Dagan, Ron; Fliss, Dan M.; Leibovitz, Eugene; Abramson, Oren; Greenberg, David; Lang, Ruth; Goshen, Swan; Yagupsky, Pablo; Leiberman, Alberto.

In: Clinical Microbiology and Infection, Vol. 3, No. SUPPL. 3, 06.1997, p. 3S43-3S48.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Antibiotic treatment in acute otitis media

T2 - 'In vivo' demonstration of antibacterial activity

AU - Dagan, Ron

AU - Fliss, Dan M.

AU - Leibovitz, Eugene

AU - Abramson, Oren

AU - Greenberg, David

AU - Lang, Ruth

AU - Goshen, Swan

AU - Yagupsky, Pablo

AU - Leiberman, Alberto

PY - 1997/6

Y1 - 1997/6

N2 - The ultimate goal in antibiotic treatment of acute otitis media (AOM) is eradication of the pathogens from the middle ear fluid (MEF). To test the ability of an antibiotic to achieve this goal, the best available method is to obtain MEF by aspiration before initiating antibiotics and to repeat this procedure during treatment, a method which was termed the 'in vivo sensitivity test'. This advantageous method is difficult to perform and thus only a few groups were able to conduct such large-scale studies. The available information is discussed in the present manuscript, as well as some preliminary results suggesting that oral β-lactam antibiotics may not be the ideal drugs to date, due to the emergence of resistant pneumococci.

AB - The ultimate goal in antibiotic treatment of acute otitis media (AOM) is eradication of the pathogens from the middle ear fluid (MEF). To test the ability of an antibiotic to achieve this goal, the best available method is to obtain MEF by aspiration before initiating antibiotics and to repeat this procedure during treatment, a method which was termed the 'in vivo sensitivity test'. This advantageous method is difficult to perform and thus only a few groups were able to conduct such large-scale studies. The available information is discussed in the present manuscript, as well as some preliminary results suggesting that oral β-lactam antibiotics may not be the ideal drugs to date, due to the emergence of resistant pneumococci.

KW - Antibiotic treatment

KW - Bacteriology

KW - Otitis media

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JF - Clinical Microbiology and Infection

SN - 1198-743X

IS - SUPPL. 3

ER -

Antibiotic treatment in acute otitis media: 'In vivo' demonstration of antibacterial activity

Abstract

Keywords

UN SDGs

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