Antibacterial temporary restorative materials incorporating polyethyleneimine nanoparticles

Itzhak Abramovitz, Nurit Beyth*, Yafit Paz, Ervin I. Weiss, Shlomo Matalon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objectives:Temporary restorative materials (TRMs) often rapidly lose their dimensional stability and antibacterial properties after exposure to humidity and bacterial Infection. Quaternary ammonium polyethyleneimine (QPEI) nanoparticles (NP) are long-lasting, sta-ble, biocompatible, and nonvolatile antibacterial polymers. In the present study, we Incor-porated QPEI NP Into standard TRMs and examined their influence on dimensional stability and their ability to reduce bacterial leakage. Method and Materials: A modified split-chamber model was used in vitro to test calcium sulfate-based and zinc oxlde-eugenol-based TRMs (Coltosol and IRM, respectively). Both materials were tested with and without 2% wt/wt Incorporated QPEI NP for fluid and bacterial leakage. Results: The calcium sulfate-based TRM displayed the lowest mlcroleakage and highest antibacterial resistance. Two-way ANOVA analysis of the fluid transport test results showed that Incor-poration of 2% wt/wt QPEI NP significantly Increased the sealing ability of both TRMs (P< .01). Analysis of survival curves by the Kaplan-Meier method showed that the calcium sulfate-based TRM with 2% wt/wt QPEI NP survived the bacterial load significantly more effectively than did the zinc oxide-eugenol-based TRM (P< .0001). Conclusion: Incorporation of 2% w/w QPEI NP may prominently improve the sealability and the antibac-terial properties of TRMs. TRMs Incorporating antibacterial nanoparticles may be clinically advantageous for sealing the endodontic access cavity to avoid reinfection of the root canal system during endodontic treatment.

Original languageEnglish
Pages (from-to)209-216
Number of pages8
JournalQuintessence International
Issue number3
StatePublished - 2013


  • Nanoparticles
  • Polyethyleneimine
  • Temporary restorative materials


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