Antiarrhythmic action of naloxone: Direct, non-opiate effect on the rat heart

Y. Sarne; I. Hochman; M. Eshed; E. Oppenheimer

doi:10.1016/0024-3205(88)90513-9

Antiarrhythmic action of naloxone: Direct, non-opiate effect on the rat heart

Y. Sarne^*, I. Hochman, M. Eshed, E. Oppenheimer

^*Corresponding author for this work

Physiology Pharmacology

Research output: Contribution to journal › Article › peer-review

Abstract

The opiate antagonist naloxone reduced the incidence and severity of cardiac arrhythmia induced in rats by intracarotid administration of adrenaline. Naloxone also reversed the adrenaline-induced arrhythmia in isolated heart preparations, suggesting a local antiarrhythmic action of the opiate antagonist. Similar effects were obtained with the (+) stereoisomer of naloxone which is inactive as an opiate antagonist. Thus, the direct action of naloxone at the rat heart is probably not mediated by opiate receptors.

Original language	English
Pages (from-to)	859-864
Number of pages	6
Journal	Life Sciences
Volume	43
Issue number	10
DOIs	https://doi.org/10.1016/0024-3205(88)90513-9
State	Published - 1988

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10.1016/0024-3205(88)90513-9

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@article{3b5f0a3b39de481eb3a504cee6d642b4,

title = "Antiarrhythmic action of naloxone: Direct, non-opiate effect on the rat heart",

abstract = "The opiate antagonist naloxone reduced the incidence and severity of cardiac arrhythmia induced in rats by intracarotid administration of adrenaline. Naloxone also reversed the adrenaline-induced arrhythmia in isolated heart preparations, suggesting a local antiarrhythmic action of the opiate antagonist. Similar effects were obtained with the (+) stereoisomer of naloxone which is inactive as an opiate antagonist. Thus, the direct action of naloxone at the rat heart is probably not mediated by opiate receptors.",

author = "Y. Sarne and I. Hochman and M. Eshed and E. Oppenheimer",

note = "Funding Information: We thank Dr. R.S. Rapaka of NIDA for the generous gift of (+)naloxone, and Du Pont Company for the generous supply of naloxone hydrochloride. This study was supported by a grant from the letber Foundation to Y. Sarne.",

year = "1988",

doi = "10.1016/0024-3205(88)90513-9",

language = "אנגלית",

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T1 - Antiarrhythmic action of naloxone

T2 - Direct, non-opiate effect on the rat heart

AU - Sarne, Y.

AU - Hochman, I.

AU - Eshed, M.

AU - Oppenheimer, E.

N1 - Funding Information: We thank Dr. R.S. Rapaka of NIDA for the generous gift of (+)naloxone, and Du Pont Company for the generous supply of naloxone hydrochloride. This study was supported by a grant from the letber Foundation to Y. Sarne.

PY - 1988

Y1 - 1988

N2 - The opiate antagonist naloxone reduced the incidence and severity of cardiac arrhythmia induced in rats by intracarotid administration of adrenaline. Naloxone also reversed the adrenaline-induced arrhythmia in isolated heart preparations, suggesting a local antiarrhythmic action of the opiate antagonist. Similar effects were obtained with the (+) stereoisomer of naloxone which is inactive as an opiate antagonist. Thus, the direct action of naloxone at the rat heart is probably not mediated by opiate receptors.

AB - The opiate antagonist naloxone reduced the incidence and severity of cardiac arrhythmia induced in rats by intracarotid administration of adrenaline. Naloxone also reversed the adrenaline-induced arrhythmia in isolated heart preparations, suggesting a local antiarrhythmic action of the opiate antagonist. Similar effects were obtained with the (+) stereoisomer of naloxone which is inactive as an opiate antagonist. Thus, the direct action of naloxone at the rat heart is probably not mediated by opiate receptors.

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EP - 864

JO - Life Sciences

JF - Life Sciences

IS - 10

ER -

Antiarrhythmic action of naloxone: Direct, non-opiate effect on the rat heart

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