@article{3b5f0a3b39de481eb3a504cee6d642b4,
title = "Antiarrhythmic action of naloxone: Direct, non-opiate effect on the rat heart",
abstract = "The opiate antagonist naloxone reduced the incidence and severity of cardiac arrhythmia induced in rats by intracarotid administration of adrenaline. Naloxone also reversed the adrenaline-induced arrhythmia in isolated heart preparations, suggesting a local antiarrhythmic action of the opiate antagonist. Similar effects were obtained with the (+) stereoisomer of naloxone which is inactive as an opiate antagonist. Thus, the direct action of naloxone at the rat heart is probably not mediated by opiate receptors.",
author = "Y. Sarne and I. Hochman and M. Eshed and E. Oppenheimer",
note = "Funding Information: We thank Dr. R.S. Rapaka of NIDA for the generous gift of (+)naloxone, and Du Pont Company for the generous supply of naloxone hydrochloride. This study was supported by a grant from the letber Foundation to Y. Sarne.",
year = "1988",
doi = "10.1016/0024-3205(88)90513-9",
language = "אנגלית",
volume = "43",
pages = "859--864",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "10",
}