Antiarrhythmic action of naloxone: Direct, non-opiate effect on the rat heart

Y. Sarne*, I. Hochman, M. Eshed, E. Oppenheimer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The opiate antagonist naloxone reduced the incidence and severity of cardiac arrhythmia induced in rats by intracarotid administration of adrenaline. Naloxone also reversed the adrenaline-induced arrhythmia in isolated heart preparations, suggesting a local antiarrhythmic action of the opiate antagonist. Similar effects were obtained with the (+) stereoisomer of naloxone which is inactive as an opiate antagonist. Thus, the direct action of naloxone at the rat heart is probably not mediated by opiate receptors.

Original languageEnglish
Pages (from-to)859-864
Number of pages6
JournalLife Sciences
Issue number10
StatePublished - 1988


FundersFunder number
letber Foundation


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