Antiandrogenic agents as monotherapy in advanced prostatic carcinoma

Mark S. Soloway, Haim Matzkin

Research output: Contribution to journalArticlepeer-review


Pure antiandrogens have a quality‐of‐life advantage over other androgen ablation methods in the treatment of patients with prostatic cancer because they do not reduce the serum testosterone and therefore do not have a marked inhibitory effect on libido and potency. The long half‐life of two of the three currently studied pure antiandrogens permits once‐a‐day administration, which should enhance patient compliance. With continued administration, there is a gradual rise in serum testosterone, and the clinical impact of this requires additional study using randomized Phase III trials. Proper stratification of patients at entry into such studies with documentation of various prognostic factors will add statistical value and enable physicians to draw better conclusion on the relative efficacy of these agents.

Original languageEnglish
Pages (from-to)1083-1088
Number of pages6
Issue number3 S
StatePublished - 1 Feb 1993
Externally publishedYes


  • antiandrogens
  • neoplasm
  • prognostic factors
  • prostate


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