TY - CHAP
T1 - Anti-Saccharomyces cerevisiae Antibodies and Autoimmune Diseases
AU - Lerman, Tsahi T.
AU - Cohen, Eytan
AU - Krause, Ilan
N1 - Publisher Copyright:
© 2024 Elsevier B.V. All rights reserved.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - The introduction of anti-Saccharomyces cerevisiae antibodies (ASCAs) in recent decades has provided a major diagnostic tool for differentiating between Crohn’s disease (CD) and ulcerative colitis (UC) in inflammatory bowel disease (IBD) patients. Furthermore, ASCAs may be useful in identifying relatives of IBD patients who are at risk of the development of the disease. Although ASCAs were claimed to be quite specific for CD, a growing number of studies have identified high levels of ASCAs in several other autoimmune diseases, such as Behcet’s disease, celiac disease, spondyloarthropathies, autoimmune liver diseases, and systemic lupus erythematosus. Therefore, we may not be dealing with a CD-specific antibody, but rather a panel of ASCA-associated diseases, of which CD is the prototype. The possible pathogenic potential of ASCAs requires further investigation, in both human patients and experimental animal models.
AB - The introduction of anti-Saccharomyces cerevisiae antibodies (ASCAs) in recent decades has provided a major diagnostic tool for differentiating between Crohn’s disease (CD) and ulcerative colitis (UC) in inflammatory bowel disease (IBD) patients. Furthermore, ASCAs may be useful in identifying relatives of IBD patients who are at risk of the development of the disease. Although ASCAs were claimed to be quite specific for CD, a growing number of studies have identified high levels of ASCAs in several other autoimmune diseases, such as Behcet’s disease, celiac disease, spondyloarthropathies, autoimmune liver diseases, and systemic lupus erythematosus. Therefore, we may not be dealing with a CD-specific antibody, but rather a panel of ASCA-associated diseases, of which CD is the prototype. The possible pathogenic potential of ASCAs requires further investigation, in both human patients and experimental animal models.
KW - ASCA
KW - Behcet’s disease
KW - Celiac disease
KW - Crohn’s disease
KW - Ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=85189598041&partnerID=8YFLogxK
U2 - 10.1016/B978-0-323-99130-8.00008-8
DO - 10.1016/B978-0-323-99130-8.00008-8
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AN - SCOPUS:85189598041
SN - 9780323991315
SP - 115
EP - 127
BT - Infection and Autoimmunity
PB - Elsevier
ER -