Anti-Ro(SSA) antibodies in patients with rheumatoid arthritis a possible marker for gold induced side effects

M. Tishler, B. Golbrut, Y. Shoenfeld, M. Yaron

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. To determine whether anti-Ro antibodies are associated with gold induced side effects. Methods. A retrospective chart review of 208 patients with rheumatoid arthritis (RA) and examination of sera for the presence of anti-Ro antibodies by enzyme linked immunosorbent assay. Results. Anti-Ro antibodies were detected in 44 (21%) of our patients with RA and their presence correlated with positive rheumatoid factor, antinuclear antibody, and secondary Sjogren's syndrome. Thirty-three out of 48 patients with gold induced side effects (69%) were anti-Ro positive in contrast to 11 patients (7.5%) with positive antibodies with no side effects (p < 0.001). Mucocutaneous reactions had the only significant correlation (p < 0.01) with the presence of anti-Ro antibodies. Conclusion. Patients with RA with anti-Ro antibodies are prone to develop mucocutaneous side effects to gold salts.

Original languageEnglish
Pages (from-to)1040-1042
Number of pages3
JournalJournal of Rheumatology
Volume21
Issue number6
StatePublished - 1994
Externally publishedYes

Keywords

  • Anti-Ro
  • Gold
  • Rheumatoid arthritis
  • Side effects

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