Abstract
Objective. To determine whether anti-Ro antibodies are associated with gold induced side effects. Methods. A retrospective chart review of 208 patients with rheumatoid arthritis (RA) and examination of sera for the presence of anti-Ro antibodies by enzyme linked immunosorbent assay. Results. Anti-Ro antibodies were detected in 44 (21%) of our patients with RA and their presence correlated with positive rheumatoid factor, antinuclear antibody, and secondary Sjogren's syndrome. Thirty-three out of 48 patients with gold induced side effects (69%) were anti-Ro positive in contrast to 11 patients (7.5%) with positive antibodies with no side effects (p < 0.001). Mucocutaneous reactions had the only significant correlation (p < 0.01) with the presence of anti-Ro antibodies. Conclusion. Patients with RA with anti-Ro antibodies are prone to develop mucocutaneous side effects to gold salts.
| Original language | English |
|---|---|
| Pages (from-to) | 1040-1042 |
| Number of pages | 3 |
| Journal | Journal of Rheumatology |
| Volume | 21 |
| Issue number | 6 |
| State | Published - 1994 |
| Externally published | Yes |
Keywords
- Anti-Ro
- Gold
- Rheumatoid arthritis
- Side effects