Anti-Rnp antibodies in chronic liver diseases

F. Konikoff, Y. Shoenfeld, D. A. Isenberg, I. Barrison, T. Sobe, E. Theodor, H. Slor

Research output: Contribution to journalArticlepeer-review


Antinuclear antibodies are commonly observed in chronic liver disorders. Sera from 87 patients with various chronic liver diseases were tested for the presence of antibodies against two extractable nuclear antigens (ENA) - RNP and Sm. Using an enzyme-linked immunosorbent assay (ELISA) anti-RNP antibodies were detected in 13 patients (15%) most of whom had cryptogenic or primary biliary cirrhosis. When the sera were further tested by ELISA for the presence of anti-Sm antibodies no antibody binding could be detected. These findings support the notion that anti-RNP (but not anti-Sm) antibodies are included among the autoantibodies shared by systemic lupus erythematosus and chronic liver diseases.

Original languageEnglish
Pages (from-to)359-361
Number of pages3
JournalClinical and Experimental Rheumatology
Issue number4
StatePublished - 1987
Externally publishedYes


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