Anti PCSK9 Monoclonal Antibody Treatment in Elderly Patients: A Real-world Clinical Experience

Eia Giladi*, Roy Israel, Wasseem Daud, Chen Gurevitz, Alaa Atamna, David Pereg, Abid Assali, Avishay Elis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: The use of proprotein convertase subtili-sin/kexin type 9 monoclonal antibodies (PCSK9 mAbs) is emerging for lowering low-density lipoprotein cholesterol (LDL-C). However, real-world data is lacking for their use among elderly patients. Objective: To define the characteristics of elderly patients treated with PCSK9 mAbs and to evaluate the efficacy and tolerability compared with younger patients. Methods: We conducted a retrospective cohort study of elderly patients (≥ 75 years at enrollment) treated with PCSK9 mAbs for primary and secondary cardiovascular prevention. Data were retrieved for demographic and clinical characteristics; indications for treatment; agents and dosages; concomitant lipid lowering treatment; LDL-C levels at baseline, 6,12 months, and at the end of follow up. Data also included achieving LDL-C target levels and adverse effects. Results: The cohort included 91 elderly patients and 92 younger patients, mean age 75.2 ± 3.76 and 58.9 ± 7.4 years [P < 0.0001). Most patients (82%, 80%) were in high/very high-risk categories. For almost all (98%, 99%), the indication was statin intolerance, with PCSK9 mAb monotherapy the most prevalent regimen. The average follow-up was 38.1 ± 20.5 and 30.9 ± 15.8 months (P= 0.0258). Within 6 months the LDL-C levels were reduced by 57% in the elderly group and by 59% in the control group (P = 0.2371). Only 53% and 57% reached their LDL-C target levels. No clinically significant side effects were documented. Conclusion: PCSK9 mAbs have similar effects and are well tolerated among elderly patients as in younger patients.

Original languageEnglish
Pages (from-to)130-135
Number of pages6
JournalIsrael Medical Association Journal
Volume26
Issue number2
StatePublished - Feb 2024

Keywords

  • elderly
  • low-density lipoprotein cholesterol (LDL-C)
  • pro-protein convertase subtilisin/kexin type 9 monoclonal antibodies (PCSK9 mAbs)
  • statins

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