Anti-P ribosomal antibodies induce defect in smell capability in a model of CNS -SLE (depression)

Aviva Katzav, Tal Ben-Ziv, Joab Chapman, Miri Blank, Morris Reichlin, Yehuda Shoenfeld*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations


Systemic lupus erythematosus (SLE) is an autoimmune disease associated with more than 100 different autoantibodies, some of which may be associated with specific neuropsychiatric (NPSLE) manifestations. Injection of anti-P ribosomal antibodies (anti-P) directly to the brain ventricles of mice induces depression manifested by increased immobility time in the forced swim test (FST). Methods: Mice were injected intracerebroventricularily (ICV) with affinity-purified human anti-P antibodies or normal commercial IgG as control. Mice were examined for depression by the forced swimming test (FST) and for olfactory function by the smell threshold test. Treatments included the antidepressant drug fluoxetine or aroma therapy by exposure to lemon or cinnamon odor. Results: Mice injected with anti-P developed depression-like behavior, which improved significantly upon treatment with fluoxetine. Depressed mice had a significant deficit in olfactory function which was not reversed by fluoxetine. Exposure of anti-P-injected mice to lemon odor was associated with some improvement of the immobility time, a measure of depression. Conclusions: ICV injection of anti-P induces both depression-like behavior and impaired olfactory function in mice. Fluoxetine and possibly lemon odor exposure improve depressive behavior in these mice.

Original languageEnglish
Pages (from-to)393-398
Number of pages6
JournalJournal of Autoimmunity
Issue number4
StatePublished - Dec 2008


FundersFunder number
National Institute of Arthritis and Musculoskeletal and Skin DiseasesP30AR053483
National Center for Research ResourcesP20RR015577


    • Animal model
    • Anti-P antibodies
    • Depression
    • Neuropsychiatric SLE
    • Olfaction


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