Anti-oxidative treatment with vitamin E improves peripheral vascular function in patients with diabetes mellitus and Haptoglobin 2-2 genotype: A double-blinded cross-over study

Jonia Amer Alshiek, Lior Dayan*, Rabea Asleh, Shany Blum, Andrew P. Levy, Giris Jacob

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Vascular dysfunction in both conduit arteries and small vessels is a major contributor to the development of cardiovascular disease (CVD) in diabetes mellitus (DM). In diabetes there is a process of systemic chronic inflammation accompanied by high oxidative stress causing a subsequent decrease in vascular reactivity and negatively affect the metabolic processes responsible for functioning of the microvasculature. Vitamin E is classified as an antioxidant due to its ability to scavenge lipid radicals and terminate oxidative chain reactions. We conducted a double-blinded cross-over study with vitamin E versus placebo in individuals with type 2 DM and the Hp2-2 genotype and assessed different aspects of peripheral vascular function in these patients. Twenty patients completed the study with 10 individuals in each study cohort. We were able to show significant improvement of indirect indices of vascular function following 8 weeks of treatment with vitamin E. This improvement was consistent for weeks even after stopping the vitamin E treatment. We concluded that a pharmacogenomic rationale utilizing the Hp genotype might potentially provide cardiovascular benefit with vitamin E.

Original languageEnglish
Pages (from-to)200-207
Number of pages8
JournalDiabetes Research and Clinical Practice
Volume131
DOIs
StatePublished - Sep 2017

Keywords

  • Anti-oxidant
  • Blood flow
  • Diabetes mellitus
  • Haptoglobin
  • Vascular function
  • Vitamin E

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