Anti-neuronal antibodies in antiphospholipid syndrome with central nervous system involvement: The difference from systemic lupus erythematosus

M. Tishler; I. Alosachie; Y. Chapman; A. Korcyn; M. Lorber; D. Mevorach; D. Tane; N. Barka; H. C. Lin; D. Alarcon-Segovia; P. Youinou; J. B. Peter; Y. Shoenfeld

doi:10.1177/096120339500400212

Anti-neuronal antibodies in antiphospholipid syndrome with central nervous system involvement: The difference from systemic lupus erythematosus

M. Tishler, I. Alosachie, Y. Chapman, A. Korcyn, M. Lorber, D. Mevorach, D. Tane, N. Barka, H. C. Lin, D. Alarcon-Segovia, P. Youinou, J. B. Peter, Y. Shoenfeld^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The presence of antineuronal antibodies was compared in 43 patients with primary aPLS and 57 patients with neuropsychiatric SLE. Fifty-eight patients with Guillain-Barre syndrome and 72 normal healthy donors served as control groups. Seventeen patients in the study group had aPLS associated with CNS involvement. Antineuronal antibodies were studied in the sera employing a novel flow cytometric assay. The frequency of antineuronal antibodies in patients with aPLS and CNS involvement was not significantly different from that of patients with aPLS without CNS disease or from that found in the control groups (12%, 19% and 7%, respectively). However, it was significantly different from that found in SLE patients with CNS involvement (60%) (P < 0.001). Our results provide further evidence that unlike CNS-SLE, the major mechanism of CNS involvement in patients with primary aPLS might not be autoantibody (antineuronal) mediated, but rather 'thrombotic' in origin, or due to yet unknown factors.

Original language	English
Pages (from-to)	145-147
Number of pages	3
Journal	Lupus
Volume	4
Issue number	2
DOIs	https://doi.org/10.1177/096120339500400212
State	Published - 1995
Externally published	Yes

Keywords

Antineuronal antibodies
Antiphospholipid syndrome
Autoimmunity
CNS

Access to Document

10.1177/096120339500400212

Cite this

Tishler, M., Alosachie, I., Chapman, Y., Korcyn, A., Lorber, M., Mevorach, D., Tane, D., Barka, N., Lin, H. C., Alarcon-Segovia, D., Youinou, P., Peter, J. B., & Shoenfeld, Y. (1995). Anti-neuronal antibodies in antiphospholipid syndrome with central nervous system involvement: The difference from systemic lupus erythematosus. Lupus, 4(2), 145-147. https://doi.org/10.1177/096120339500400212

@article{0200ca7d1d3045b79f009800cec874b8,

title = "Anti-neuronal antibodies in antiphospholipid syndrome with central nervous system involvement: The difference from systemic lupus erythematosus",

abstract = "The presence of antineuronal antibodies was compared in 43 patients with primary aPLS and 57 patients with neuropsychiatric SLE. Fifty-eight patients with Guillain-Barre syndrome and 72 normal healthy donors served as control groups. Seventeen patients in the study group had aPLS associated with CNS involvement. Antineuronal antibodies were studied in the sera employing a novel flow cytometric assay. The frequency of antineuronal antibodies in patients with aPLS and CNS involvement was not significantly different from that of patients with aPLS without CNS disease or from that found in the control groups (12%, 19% and 7%, respectively). However, it was significantly different from that found in SLE patients with CNS involvement (60%) (P < 0.001). Our results provide further evidence that unlike CNS-SLE, the major mechanism of CNS involvement in patients with primary aPLS might not be autoantibody (antineuronal) mediated, but rather 'thrombotic' in origin, or due to yet unknown factors.",

keywords = "Antineuronal antibodies, Antiphospholipid syndrome, Autoimmunity, CNS",

author = "M. Tishler and I. Alosachie and Y. Chapman and A. Korcyn and M. Lorber and D. Mevorach and D. Tane and N. Barka and Lin, {H. C.} and D. Alarcon-Segovia and P. Youinou and Peter, {J. B.} and Y. Shoenfeld",

year = "1995",

doi = "10.1177/096120339500400212",

language = "אנגלית",

volume = "4",

pages = "145--147",

journal = "Lupus",

issn = "0961-2033",

publisher = "SAGE Publications Ltd",

number = "2",

}

Tishler, M, Alosachie, I, Chapman, Y, Korcyn, A, Lorber, M, Mevorach, D, Tane, D, Barka, N, Lin, HC, Alarcon-Segovia, D, Youinou, P, Peter, JB & Shoenfeld, Y 1995, 'Anti-neuronal antibodies in antiphospholipid syndrome with central nervous system involvement: The difference from systemic lupus erythematosus', Lupus, vol. 4, no. 2, pp. 145-147. https://doi.org/10.1177/096120339500400212

TY - JOUR

T1 - Anti-neuronal antibodies in antiphospholipid syndrome with central nervous system involvement

T2 - The difference from systemic lupus erythematosus

AU - Tishler, M.

AU - Alosachie, I.

AU - Chapman, Y.

AU - Korcyn, A.

AU - Lorber, M.

AU - Mevorach, D.

AU - Tane, D.

AU - Barka, N.

AU - Lin, H. C.

AU - Alarcon-Segovia, D.

AU - Youinou, P.

AU - Peter, J. B.

AU - Shoenfeld, Y.

PY - 1995

Y1 - 1995

N2 - The presence of antineuronal antibodies was compared in 43 patients with primary aPLS and 57 patients with neuropsychiatric SLE. Fifty-eight patients with Guillain-Barre syndrome and 72 normal healthy donors served as control groups. Seventeen patients in the study group had aPLS associated with CNS involvement. Antineuronal antibodies were studied in the sera employing a novel flow cytometric assay. The frequency of antineuronal antibodies in patients with aPLS and CNS involvement was not significantly different from that of patients with aPLS without CNS disease or from that found in the control groups (12%, 19% and 7%, respectively). However, it was significantly different from that found in SLE patients with CNS involvement (60%) (P < 0.001). Our results provide further evidence that unlike CNS-SLE, the major mechanism of CNS involvement in patients with primary aPLS might not be autoantibody (antineuronal) mediated, but rather 'thrombotic' in origin, or due to yet unknown factors.

AB - The presence of antineuronal antibodies was compared in 43 patients with primary aPLS and 57 patients with neuropsychiatric SLE. Fifty-eight patients with Guillain-Barre syndrome and 72 normal healthy donors served as control groups. Seventeen patients in the study group had aPLS associated with CNS involvement. Antineuronal antibodies were studied in the sera employing a novel flow cytometric assay. The frequency of antineuronal antibodies in patients with aPLS and CNS involvement was not significantly different from that of patients with aPLS without CNS disease or from that found in the control groups (12%, 19% and 7%, respectively). However, it was significantly different from that found in SLE patients with CNS involvement (60%) (P < 0.001). Our results provide further evidence that unlike CNS-SLE, the major mechanism of CNS involvement in patients with primary aPLS might not be autoantibody (antineuronal) mediated, but rather 'thrombotic' in origin, or due to yet unknown factors.

KW - Antineuronal antibodies

KW - Antiphospholipid syndrome

KW - Autoimmunity

KW - CNS

UR - http://www.scopus.com/inward/record.url?scp=0028929554&partnerID=8YFLogxK

U2 - 10.1177/096120339500400212

DO - 10.1177/096120339500400212

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 7795619

AN - SCOPUS:0028929554

SN - 0961-2033

VL - 4

SP - 145

EP - 147

JO - Lupus

JF - Lupus

IS - 2

ER -

Anti-neuronal antibodies in antiphospholipid syndrome with central nervous system involvement: The difference from systemic lupus erythematosus

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this