Anti-Ia antibodies inhibit the spontaneous secretion of IL-1 from silicotic rat alveolar macrophages

D. Struhar; R. J. Harbeck

doi:10.1016/0165-2478(89)90151-X

Anti-Ia antibodies inhibit the spontaneous secretion of IL-1 from silicotic rat alveolar macrophages

D. Struhar^*, R. J. Harbeck

^*Corresponding author for this work

National Jewish Medical and Research Center

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Class II antigens of the major histocompatibility complex (Ia) are important components in the investigation of cell-mediated immune responses. Several reports have indicated that anti-Ia monoclonal antibodies suppress disease development in animal models. In this paper, the expression of Ia and the effect of anti-Ia on IL-1 secretion from alveolar macrophages (AM) from silica-treated rats was examined. The results obtained showed that 45% of silicotic AM, but only 5% of AM from normal control rats, express Ia antigen. Anti-Ia treatment of silicotic AM reduced IL-1 secretion by 55%. We conclude that anti-Ia immune suppression may involve the inhibition of IL-1 secretion.

Original language	English
Pages (from-to)	31-33
Number of pages	3
Journal	Immunology Letters
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/0165-2478(89)90151-X
State	Published - Nov 1989
Externally published	Yes

Keywords

Alveolar macrophage
Ia
Interleukin I
Silica

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10.1016/0165-2478(89)90151-X

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title = "Anti-Ia antibodies inhibit the spontaneous secretion of IL-1 from silicotic rat alveolar macrophages",

abstract = "Class II antigens of the major histocompatibility complex (Ia) are important components in the investigation of cell-mediated immune responses. Several reports have indicated that anti-Ia monoclonal antibodies suppress disease development in animal models. In this paper, the expression of Ia and the effect of anti-Ia on IL-1 secretion from alveolar macrophages (AM) from silica-treated rats was examined. The results obtained showed that 45% of silicotic AM, but only 5% of AM from normal control rats, express Ia antigen. Anti-Ia treatment of silicotic AM reduced IL-1 secretion by 55%. We conclude that anti-Ia immune suppression may involve the inhibition of IL-1 secretion.",

keywords = "Alveolar macrophage, Ia, Interleukin I, Silica",

author = "D. Struhar and Harbeck, {R. J.}",

year = "1989",

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N2 - Class II antigens of the major histocompatibility complex (Ia) are important components in the investigation of cell-mediated immune responses. Several reports have indicated that anti-Ia monoclonal antibodies suppress disease development in animal models. In this paper, the expression of Ia and the effect of anti-Ia on IL-1 secretion from alveolar macrophages (AM) from silica-treated rats was examined. The results obtained showed that 45% of silicotic AM, but only 5% of AM from normal control rats, express Ia antigen. Anti-Ia treatment of silicotic AM reduced IL-1 secretion by 55%. We conclude that anti-Ia immune suppression may involve the inhibition of IL-1 secretion.

AB - Class II antigens of the major histocompatibility complex (Ia) are important components in the investigation of cell-mediated immune responses. Several reports have indicated that anti-Ia monoclonal antibodies suppress disease development in animal models. In this paper, the expression of Ia and the effect of anti-Ia on IL-1 secretion from alveolar macrophages (AM) from silica-treated rats was examined. The results obtained showed that 45% of silicotic AM, but only 5% of AM from normal control rats, express Ia antigen. Anti-Ia treatment of silicotic AM reduced IL-1 secretion by 55%. We conclude that anti-Ia immune suppression may involve the inhibition of IL-1 secretion.

KW - Alveolar macrophage

KW - Ia

KW - Interleukin I

KW - Silica

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Anti-Ia antibodies inhibit the spontaneous secretion of IL-1 from silicotic rat alveolar macrophages

Abstract

Keywords

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