Anti-DFS70 autoantibodies in undifferentiated connective tissue diseases subjects: What's on the horizon?

Maria Infantino, Ora Shovman, Dolores Pérez, Mariangela Manfredi, Valentina Grossi, Maurizio Benucci, Francesca Li Gobbi, Francesca Bandinelli, Arianna Damiani, Paolo Moscato, Danielle Azoulay, Boris Gilburd, Yehuda Shoenfeld

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. The main objective was to determine the prevalence of anti-dense fine speckled (DFS70) antibodies in a stable population of undifferentiated connective tissue disease (UCTD) to better define their potential role. Methods. Immunological and clinical records of 91 long-standing UCTD patients were studied. DFS pattern was determined using the IIF ANA test on HEp-2 cells and anti-DFS70 antibodies were tested by chemiluminescence assay and by DFS70 line immunoassay. Results. Twelve (13.2%) of 91 serum samples were positive for anti-DFS70 antibodies by chemiluminescence assay and line immunoassay. There was no statistical significance between the prevalence of anti-ENA and anti- DNA autoantibodies in patients with and without anti-DFS70 antibodies. No differences were found in the clinical characteristics of both groups. The presence of the anti-DFS70 antibodies was related to the younger age class. Conclusion. The high prevalence of anti-DFS70 antibodies in the UCTD patients suggested the potential role of these autoantibodies as a marker in the evolution of UCTD to CTD.

Original languageEnglish
Pages (from-to)1293-1298
Number of pages6
JournalRheumatology
Volume57
Issue number7
DOIs
StatePublished - 1 Jul 2018
Externally publishedYes

Keywords

  • Anti-DFS70 antibodies
  • Antinuclear antibodies
  • Undifferentiated connective tissue disease

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