TY - JOUR
T1 - Anti-DFS70 autoantibodies in undifferentiated connective tissue diseases subjects
T2 - What's on the horizon?
AU - Infantino, Maria
AU - Shovman, Ora
AU - Pérez, Dolores
AU - Manfredi, Mariangela
AU - Grossi, Valentina
AU - Benucci, Maurizio
AU - Gobbi, Francesca Li
AU - Bandinelli, Francesca
AU - Damiani, Arianna
AU - Moscato, Paolo
AU - Azoulay, Danielle
AU - Gilburd, Boris
AU - Shoenfeld, Yehuda
N1 - Publisher Copyright:
© The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Rheumatology.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Objective. The main objective was to determine the prevalence of anti-dense fine speckled (DFS70) antibodies in a stable population of undifferentiated connective tissue disease (UCTD) to better define their potential role. Methods. Immunological and clinical records of 91 long-standing UCTD patients were studied. DFS pattern was determined using the IIF ANA test on HEp-2 cells and anti-DFS70 antibodies were tested by chemiluminescence assay and by DFS70 line immunoassay. Results. Twelve (13.2%) of 91 serum samples were positive for anti-DFS70 antibodies by chemiluminescence assay and line immunoassay. There was no statistical significance between the prevalence of anti-ENA and anti- DNA autoantibodies in patients with and without anti-DFS70 antibodies. No differences were found in the clinical characteristics of both groups. The presence of the anti-DFS70 antibodies was related to the younger age class. Conclusion. The high prevalence of anti-DFS70 antibodies in the UCTD patients suggested the potential role of these autoantibodies as a marker in the evolution of UCTD to CTD.
AB - Objective. The main objective was to determine the prevalence of anti-dense fine speckled (DFS70) antibodies in a stable population of undifferentiated connective tissue disease (UCTD) to better define their potential role. Methods. Immunological and clinical records of 91 long-standing UCTD patients were studied. DFS pattern was determined using the IIF ANA test on HEp-2 cells and anti-DFS70 antibodies were tested by chemiluminescence assay and by DFS70 line immunoassay. Results. Twelve (13.2%) of 91 serum samples were positive for anti-DFS70 antibodies by chemiluminescence assay and line immunoassay. There was no statistical significance between the prevalence of anti-ENA and anti- DNA autoantibodies in patients with and without anti-DFS70 antibodies. No differences were found in the clinical characteristics of both groups. The presence of the anti-DFS70 antibodies was related to the younger age class. Conclusion. The high prevalence of anti-DFS70 antibodies in the UCTD patients suggested the potential role of these autoantibodies as a marker in the evolution of UCTD to CTD.
KW - Anti-DFS70 antibodies
KW - Antinuclear antibodies
KW - Undifferentiated connective tissue disease
UR - http://www.scopus.com/inward/record.url?scp=85051549920&partnerID=8YFLogxK
U2 - 10.1093/rheumatology/key012
DO - 10.1093/rheumatology/key012
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C2 - 29618128
AN - SCOPUS:85051549920
SN - 1462-0324
VL - 57
SP - 1293
EP - 1298
JO - Rheumatology
JF - Rheumatology
IS - 7
ER -