Anti-citrullinated peptide antibodies is more than an accurate tool for diagnosis of rheumatoid arthritis

Kevin Goldman, Smadar Gertel, Howard Amital

Research output: Contribution to journalReview articlepeer-review

Abstract

Anti-citrullinated peptide antibodies (ACPA) are detected in the sera of rheumatoid arthritis (RA) patients and have a profound role in diagnosis of the disease. In this review we discuss the different cohorts of RA patients in whom the presence, sensitivity and specificity of ACPA were evaluated. The significance of ACPA in the pathogenesis and prognosis RA is also interpreted. Recent advances in the understanding of molecular pathways involved in the pathogenesis of RA have led to the identification of novel biologic agents that are now widely used in patients with RA.

Original languageEnglish
Pages (from-to)584-587
Number of pages4
JournalIsrael Medical Association Journal
Volume15
Issue number9
StatePublished - Sep 2013
Externally publishedYes

Keywords

  • Anti-CCP
  • Anti-citrullinated peptide antibodies (ACPA)
  • Citrullination
  • Rheumatoid arthritis (RA)
  • Rheumatoid factor

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