TY - JOUR
T1 - Anterograde and retrograde amnesia in a person with bilateral fornix lesions following removal of a colloid cyst
AU - Poreh, Amir
AU - Winocur, Gordon
AU - Moscovitch, Morris
AU - Backon, Matti
AU - Goshen, Elinor
AU - Ram, Zvi
AU - Feldman, Zeev
N1 - Funding Information:
At the time of the research, AP was a neuropsychologist at Sheba Medical Center, Tel Aviv, Israel. The support of the Center is gratefully acknowledged. Some of the work was conducted while GW and MM were Visiting Professors in the Psychology Department of the Hebrew University of Jerusalem. Portions of this research were supported by a grant from the Canadian Institutes of Health Research to GW and MM, and by fellowships to GW and MM from the Lady Davis Trust. MM and GW also acknowledge valuable input from Dr. Asaf Gilboa, Dr. Fuqiang Gao, and Dr. Michael Alexander.
PY - 2006
Y1 - 2006
N2 - AD, a 45-year-old man, presented with a severe and global anterograde amnesia following surgery for removal of a colloid cyst. Structural neuroimaging confirmed bilateral lesions to the fornix and a small lesion in the basal forebrain. Testing for remote episodic memory of autobiographical events, and for remote semantic memory of personal and public events, and of famous people, revealed that AD had a severe retrograde amnesia for autobiographical episodes that covered his entire lifetime, and a time-limited retrograde amnesia for semantic memory. Because the fornix and basal forebrain lesions disrupted major afferent and efferent pathways of the hippocampus, it was concluded that the integrity of the hippocampus and its projections are needed to retain and/or recover autobiographical memories no matter how old they are. By contrast, hippocampal contribution to semantic memory is time-limited. These findings were interpreted as consistent with Multiple Trace Theory, which holds that the hippocampal system is essential for recovering contextually rich memories no matter how old they are, but is not needed for recovering semantic memories.
AB - AD, a 45-year-old man, presented with a severe and global anterograde amnesia following surgery for removal of a colloid cyst. Structural neuroimaging confirmed bilateral lesions to the fornix and a small lesion in the basal forebrain. Testing for remote episodic memory of autobiographical events, and for remote semantic memory of personal and public events, and of famous people, revealed that AD had a severe retrograde amnesia for autobiographical episodes that covered his entire lifetime, and a time-limited retrograde amnesia for semantic memory. Because the fornix and basal forebrain lesions disrupted major afferent and efferent pathways of the hippocampus, it was concluded that the integrity of the hippocampus and its projections are needed to retain and/or recover autobiographical memories no matter how old they are. By contrast, hippocampal contribution to semantic memory is time-limited. These findings were interpreted as consistent with Multiple Trace Theory, which holds that the hippocampal system is essential for recovering contextually rich memories no matter how old they are, but is not needed for recovering semantic memories.
KW - Anterograde amnesia
KW - Episodic (autobiographical) memory
KW - Hippocampus
KW - Medial temporal lobes
KW - Semantic memory
UR - http://www.scopus.com/inward/record.url?scp=33745968451&partnerID=8YFLogxK
U2 - 10.1016/j.neuropsychologia.2006.05.020
DO - 10.1016/j.neuropsychologia.2006.05.020
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C2 - 16846621
AN - SCOPUS:33745968451
SN - 0028-3932
VL - 44
SP - 2241
EP - 2248
JO - Neuropsychologia
JF - Neuropsychologia
IS - 12
ER -