Anterior uveitis as a complication of treatment with high dose cytosine-arabinoside

David Planer; Tali Cukierman; Diana Liebster; Michael Ilsar; Tova Chajek-Shaul

doi:10.1002/ajh.20082

Anterior uveitis as a complication of treatment with high dose cytosine-arabinoside

David Planer^*, Tali Cukierman, Diana Liebster, Michael Ilsar, Tova Chajek-Shaul

^*Corresponding author for this work

Hadassah University Medical Centre

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We present a case of a 21-year-old woman suffering from diffuse large B-cell lymphoma who developed acute anterior uveitis shortly after completing chemotherapeutic course with HYPER-CVAD protocol (cyclophosphamide, doxorubicin, vincristine, and dexamethasone) alternating with methotrexate and high-dose cytosine-arabinoside (HIDAC), with poor adherence to recommended prophylactic treatment with saline eye drops. Complete resolution of her symptoms was achieved within a few days of treatment with topical steroids. To our knowledge this is the first report of acute anterior uveitis secondary to treatment with HIDAC. Differential diagnosis and a suggested mechanism are discussed.

Original language	English
Pages (from-to)	304-306
Number of pages	3
Journal	American Journal of Hematology
Volume	76
Issue number	3
DOIs	https://doi.org/10.1002/ajh.20082
State	Published - Jul 2004
Externally published	Yes

Keywords

Anterior uveitis
Complication
High-dose cytosine-arabinoside

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10.1002/ajh.20082

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abstract = "We present a case of a 21-year-old woman suffering from diffuse large B-cell lymphoma who developed acute anterior uveitis shortly after completing chemotherapeutic course with HYPER-CVAD protocol (cyclophosphamide, doxorubicin, vincristine, and dexamethasone) alternating with methotrexate and high-dose cytosine-arabinoside (HIDAC), with poor adherence to recommended prophylactic treatment with saline eye drops. Complete resolution of her symptoms was achieved within a few days of treatment with topical steroids. To our knowledge this is the first report of acute anterior uveitis secondary to treatment with HIDAC. Differential diagnosis and a suggested mechanism are discussed.",

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AU - Ilsar, Michael

AU - Chajek-Shaul, Tova

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AB - We present a case of a 21-year-old woman suffering from diffuse large B-cell lymphoma who developed acute anterior uveitis shortly after completing chemotherapeutic course with HYPER-CVAD protocol (cyclophosphamide, doxorubicin, vincristine, and dexamethasone) alternating with methotrexate and high-dose cytosine-arabinoside (HIDAC), with poor adherence to recommended prophylactic treatment with saline eye drops. Complete resolution of her symptoms was achieved within a few days of treatment with topical steroids. To our knowledge this is the first report of acute anterior uveitis secondary to treatment with HIDAC. Differential diagnosis and a suggested mechanism are discussed.

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Anterior uveitis as a complication of treatment with high dose cytosine-arabinoside

Abstract

Keywords

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