Antenatal risk factors for symptomatic congenital CMV disease following primary maternal CMV infection

Eran Hadar, Liat Salzer, Elizabeta Dorfman, Jacob Amir, Joseph Pardo

Research output: Contribution to journalReview articlepeer-review

Abstract

Objectives: This study aimed to evaluate antenatal risk factors associated with symptomatic congenital cytomegalovirus (CMV) disease, following in utero vertical infection. Methods: This study included a retrospective cohort of 155 neonates with congenital CMV infection, following primary maternal CMV infection during pregnancy, and were divided to symptomatic (n=95) and asymptomatic (n=60) newborns. Results: Young maternal age (29.1±5.12 vs. 31.6±5.36 years, P=0.005), high risk occupation for viral exposure (20.0% vs. 11.7%, P=0.04), CMV IgG seroconversion at diagnosis (83.1% vs. 63.3%, P=0.005) and abnormal fetal MRI (11.6% vs. 0%, P=0.003) were found to be prognostic risk factors associated with symptomatic CMV disease of the newborn. Maternal febrile illness at diagnosis, IgG avidity, US findings and the timing of maternal infection were not associated with the occurrence of neonatal symptoms. Conclusions: Knowledge of the reported risk factors may assist in counseling parents with intra uterine CMV infection.

Original languageEnglish
Pages (from-to)339-344
Number of pages6
JournalJournal of Perinatal Medicine
Volume44
Issue number3
DOIs
StatePublished - 1 Apr 2016

Keywords

  • Congenital
  • cytomegalovirus
  • infection
  • maternal
  • primary
  • risk factors

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