Antecedent Medical Diseases in Patients with Amyotrophic Lateral Sclerosis: A Population-Based Case-Controlled Study in Rochester, Minn, 1925 Through 1987

Carmel Armon, Peter C. O'brien, Donald W. Mulder, Leonard T. Kurland*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Odds ratios (ORs) were estimated for the prevalence of antecedent endocrine, metabolic, or vascular diseases among 45 patients with amyotrophic lateral sclerosis from the Rochester, Minn, population compared with 90 control subjects matched for sex, year of birth, period of observation, and residence. Hypertension occurred less frequently in male patients with amyotrophic lateral sclerosis (4%) than in control subjects (30%; OR =.10). Because of small population size, no conclusions can be drawn with respect to the following antecedent conditions: thyroid disease (OR = 1.61), coronary artery disease (OR =.58), obesity (OR =.52), diabetes (OR = 1.00), cerebrovascular disease (OR =.21), and peripheral vascular disease (OR = 1.23). The heterogeneity of antecedent thyroid disease makes it highly unlikely that any specific thyroid lesion is causally associated with most cases of amyotrophic lateral sclerosis. Hypertension may be a marker for protective factors against the development of amyotrophic lateral sclerosis in men.

Original languageEnglish
Pages (from-to)283-286
Number of pages4
JournalArchives of Neurology
Volume48
Issue number3
DOIs
StatePublished - Mar 1991
Externally publishedYes

Funding

FundersFunder number
National Institute of Neurological Disorders and StrokeP01NS017750

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