ANTAGONISM OF OPIATE MYDRIASIS IN MICE

AMOS D. KORCZYN, MEIR ROCK

Research output: Contribution to journalArticlepeer-review

Abstract

Morphine‐induced mydriasis in mice is antagonized by nalorphine, levallorphan and naloxone in a dose‐dependent manner. The relative potency of the three agents is 10: 56: 134 respectively, thus being in accordance with other tests of narcotic antagonism. Naloxone has the shortest duration of action. When injected into naive animals, nalorphine (but not levallorphan or naloxone) produces a slight mydriasis. Measurement of the diameter of the pupil in mice seems to be a precise, simple and rapid test for studying narcotic antagonist as well as agonist action and has several advantages over standard methods used for this purpose. 1981 British Pharmacological Society

Original languageEnglish
Pages (from-to)807-810
Number of pages4
JournalBritish Journal of Pharmacology
Volume73
Issue number4
DOIs
StatePublished - Aug 1981

Fingerprint

Dive into the research topics of 'ANTAGONISM OF OPIATE MYDRIASIS IN MICE'. Together they form a unique fingerprint.

Cite this