Antagonism of aldosterone in normal subjects by Ro 12-2503 and spironolactone

S. Dux, J. Rosenfeld, G. Cocco, D. Chu, D. F. Gasser

Research output: Contribution to journalArticlepeer-review


The potency and efficacy of a single dose of a new aldosterone antagonist, potassium 17a-hydroxy-6β,7β-methylene-3-oxo-D-homo-17aα-pregna-4,16-diene-21-carbox ylate (Ro 12-2503), in reversing the renal effects of exogenous aldosterone were compared to those of spironolactone, and placebo. The study was performed according to double-blind and crossover procedure in six healthy male subjects. Both drugs, spironolactone and Ro 12-2503, did not completely antagonize the effects of aldosterone. The efficacy of Ro 12-2503 in terms of the urinary Na+/K+ ratio and the urinary Na+ concentration was less than that of spironolactone. Spironolactone produced a slightly greater natriuresis, but the difference was not significant. The method described, based on standard bioassay techniques permits a comparison of the two drugs, and may prove useful in the screening and evaluation of aldosterone antagonists.

Original languageEnglish
Pages (from-to)164-169
Number of pages6
JournalArzneimittel-Forschung/Drug Research
Issue number2
StatePublished - 1982


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