Animal Models of Alzheimer's Disease

S. Amram*, D. Frenkel

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Alzheimer's disease (AD) is the most common type of dementia. The pathological characterizations of AD are the depositions of a peptide called amyloid beta and of hyper phosphorylated tau protein, gliosis, and neuronal death. While less than 5% of AD cases are caused by genetic mutations, these mutations are the basis for the majority of the animal models of AD. Although not presenting the entire spectrum of AD symptoms, these animal models extend and deepen our understanding on the pathological processes in AD and the possible therapeutic interventions. Nevertheless, many of these therapeutic applications fail later in clinical trials. Understanding the advantages and limitations of AD animal models is crucial for future therapeutic interventions.

Original languageEnglish
Title of host publicationNeuroprotection in Alzheimer's Disease
PublisherElsevier Inc.
Pages31-58
Number of pages28
ISBN (Electronic)9780128037126
ISBN (Print)9780128036907
DOIs
StatePublished - 20 Jan 2017

Keywords

  • A?
  • APP
  • Alzheimer's disease
  • ApoE
  • Inflammation
  • Tau
  • Transgenic models

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