Animal models for cerebrovascular impairment and its relevance in vascular dementia

Veronica Lifshitz, Dan Frenkel*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

6 Scopus citations


Dementia is one of the most predominant neurological disorders in the elderly. Theprevalence and incidence of degenerative diseases, such as Alzheimer s disease (AD) andvascular dementia, strongly correlate with age. Vascular dementia (VaD) is recognized asthe second most prevalent type of dementia and described as a multifaceted cognitivedecline resulting from cerebrovascular injury to brain regions associated with memory,cognition, and behavior. Vascular risk factors including diabetes, insulin resistance,hypertension, heart disease, smoking and obesity are each independently associated withan increased risk of cognitive impairment and dementia. This review will summarizerelevant animal models for studying cognitive deficits as well as diagnostic assessment ofVaD in humans with the intention of developing both an early diagnostic capability andfuture therapeutic interventions.

Original languageEnglish
Title of host publicationCognitive Impairment
Subtitle of host publicationCauses, Diagnosis and Treatments
PublisherNova Science Publishers, Inc.
Number of pages20
ISBN (Print)9781608762057
StatePublished - Apr 2009


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