Abstract
Dementia is one of the most predominant neurological disorders in the elderly. Theprevalence and incidence of degenerative diseases, such as Alzheimer s disease (AD) andvascular dementia, strongly correlate with age. Vascular dementia (VaD) is recognized asthe second most prevalent type of dementia and described as a multifaceted cognitivedecline resulting from cerebrovascular injury to brain regions associated with memory,cognition, and behavior. Vascular risk factors including diabetes, insulin resistance,hypertension, heart disease, smoking and obesity are each independently associated withan increased risk of cognitive impairment and dementia. This review will summarizerelevant animal models for studying cognitive deficits as well as diagnostic assessment ofVaD in humans with the intention of developing both an early diagnostic capability andfuture therapeutic interventions.
| Original language | English |
|---|---|
| Title of host publication | Cognitive Impairment |
| Subtitle of host publication | Causes, Diagnosis and Treatments |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 141-160 |
| Number of pages | 20 |
| ISBN (Print) | 9781608762057 |
| State | Published - Apr 2009 |
