TY - JOUR
T1 - Anhedonia is associated with a specific depression profile and poor antidepressant response
AU - Luca, Antonina
AU - Luca, Maria
AU - Kasper, Siegfried
AU - Pecorino, Basilio
AU - Zohar, Joseph
AU - Souery, Daniel
AU - Montgomery, Stuart
AU - Ferentinos, Panagiotis
AU - Rujescu, Dan
AU - Messina, Antonino
AU - Zanardi, Raffaella
AU - Ferri, Raffaele
AU - Tripodi, Mariangela
AU - Baune, Bernhard T.
AU - Fanelli, Giuseppe
AU - Fabbri, Chiara
AU - Mendlewicz, Julien
AU - Serretti, Alessandro
N1 - Publisher Copyright:
© 2024 The Author(s).
PY - 2024/12/1
Y1 - 2024/12/1
N2 - Background: Anhedonic features within major depressive disorder (MDD) have been associated with worse course and outcome and may predict nonresponse to treatment. However, a detailed clinical profile of anhedonia in MDD is still lacking. Materials and Methods: One thousand two hundred ninety-four patients with MDD were selected from the cross-sectional European multicenter Group for the Study of Resistant Depression study. Anhedonia was assessed through the Montgomery-Åsberg Depression Rating Scale anhedonia item "inability to feel."Clinical and demographic features were then analyzed. Results: The presence of anhedonia related to a distinct demographical (living alone) and clinical profile (thyroid diseases, diabetes, suicide risk, high number of previous depressive episodes, more severe MDD, and more frequent inpatient status). Furthermore, anhedonia was associated with nonresponse to treatment and treatment resistance, even after adjusting for confounding variables. Conclusions: Our findings support the role of anhedonia as a modulating feature of MDD, being associated with a more severe depression profile. Moreover, anhedonic features are independent predictors of poor treatment response.
AB - Background: Anhedonic features within major depressive disorder (MDD) have been associated with worse course and outcome and may predict nonresponse to treatment. However, a detailed clinical profile of anhedonia in MDD is still lacking. Materials and Methods: One thousand two hundred ninety-four patients with MDD were selected from the cross-sectional European multicenter Group for the Study of Resistant Depression study. Anhedonia was assessed through the Montgomery-Åsberg Depression Rating Scale anhedonia item "inability to feel."Clinical and demographic features were then analyzed. Results: The presence of anhedonia related to a distinct demographical (living alone) and clinical profile (thyroid diseases, diabetes, suicide risk, high number of previous depressive episodes, more severe MDD, and more frequent inpatient status). Furthermore, anhedonia was associated with nonresponse to treatment and treatment resistance, even after adjusting for confounding variables. Conclusions: Our findings support the role of anhedonia as a modulating feature of MDD, being associated with a more severe depression profile. Moreover, anhedonic features are independent predictors of poor treatment response.
KW - anhedonia
KW - antidepressants
KW - major depression
KW - treatment outcomes
KW - treatment-resistant depression (TRD)
UR - http://www.scopus.com/inward/record.url?scp=85212457465&partnerID=8YFLogxK
U2 - 10.1093/ijnp/pyae055
DO - 10.1093/ijnp/pyae055
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C2 - 39521954
AN - SCOPUS:85212457465
SN - 1461-1457
VL - 27
JO - International Journal of Neuropsychopharmacology
JF - International Journal of Neuropsychopharmacology
IS - 12
M1 - pyae055
ER -
