Angiotensin converting enzyme in bleomycin-treated patients

N. Nussinovitch, E. Peleg, A. Yaron, P. Ratt, T. Rosenthal

Research output: Contribution to journalArticlepeer-review


Angiotensin converting enzyme activity (ACE) was measured in two patient groups treated with a bleomycin combination. One group, with squamous cell carcinoma was treated according to the Price et al. [1975] protocol, with low doses of bleomycin. The second group, with testicular tumors, was treated according to the Einhorn and Donohue [1977] protocol, with high doses of bleomycin. No change in serum angiotensin converting enzyme activity was observed in the low dosage group. A late and prolonged elevation, not connected to the acute injection, was observed in the high dosage group. There is an indication that the monitoring of ACE may be helpful in establishing the prognosis of the treated patients.

Original languageEnglish
Pages (from-to)310-313
Number of pages4
JournalInternational Journal of Clinical Pharmacology Therapy and Toxicology
Issue number6
StatePublished - 1988
Externally publishedYes


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