Angiogenic activity of vitreous extract obtained from rabbit eyes with endotoxin-lnduced uveitis

Nava Naveh*, Andrei Nussbaum, Howard Desatnik, Elisha Bartov

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The effect of rabbit vitreous with endotoxin-induced uveitis was investigated for its role in the modulation of rat corneal neovascularization (NV). Elvax pellets implanted into at cornea contained either uveitic vitreous, intact vitreous or Elvax alone. The latter two kinds of pellets did not elicit NV. Uveitic vitreous pellets caused, in 100% of eyes, a persistent NV with maximal growth on the 10th day post implantation. Prostaglandin E2 and leukotriene B4 levels in the uveitic rabbit vitreous at 36 h postendotoxin injection were 7- and 5-fold higher than baseline, respectively. Histopathologically, the neovascularized cornea showed a significant inflammatory reaction attributable to the uveitic vitreous extract.

Original languageEnglish
Pages (from-to)23-31
Number of pages9
JournalOphthalmic Research
Volume27
Issue number1
DOIs
StatePublished - 1995

Keywords

  • Angiogenesis
  • Cornea
  • Leukotriene B4
  • Prostaglandins type E2
  • Uveitis

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