TY - JOUR
T1 - Ancient lateral gene transfer in the evolution of Bdellovibrio bacteriovorus
AU - Gophna, Uri
AU - Charlebois, Robert L.
AU - Doolittle, W. Ford
N1 - Funding Information:
W.F.D. is supported by the Canada Research Chair Program and this research was supported by Genome Atlantic and the Canadian Institutes for Health Research. We thank Gabino F. Sanchez-Perez for codon-bias analysis, Eric Bapteste and David A. Walsh for helpful advice and Edouard Jurkevitch for critical reading of the manuscript.
PY - 2006/2
Y1 - 2006/2
N2 - The recently sequenced genome of the predatory δ-proteobacterium Bdellovibrio bacteriovorus provides many insights into its metabolism and evolution. Because its genes are reasonably uniform in G+C content, it was suggested that B. bacteriovorus actively resists recombination with foreign DNA and horizontal transfer of DNA from other bacteria. To investigate this further, we carried out a variety of phylogenetic and comparative genomics analyses using data from >200 microbial genomes, including several published δ-proteobacteria. Although there might be little evidence for the extensive recent transfer of genes, we demonstrate that ancient lateral gene acquisition has shaped the B. bacteriovorus genome to a great extent.
AB - The recently sequenced genome of the predatory δ-proteobacterium Bdellovibrio bacteriovorus provides many insights into its metabolism and evolution. Because its genes are reasonably uniform in G+C content, it was suggested that B. bacteriovorus actively resists recombination with foreign DNA and horizontal transfer of DNA from other bacteria. To investigate this further, we carried out a variety of phylogenetic and comparative genomics analyses using data from >200 microbial genomes, including several published δ-proteobacteria. Although there might be little evidence for the extensive recent transfer of genes, we demonstrate that ancient lateral gene acquisition has shaped the B. bacteriovorus genome to a great extent.
UR - http://www.scopus.com/inward/record.url?scp=31944449494&partnerID=8YFLogxK
U2 - 10.1016/j.tim.2005.12.008
DO - 10.1016/j.tim.2005.12.008
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AN - SCOPUS:31944449494
SN - 0966-842X
VL - 14
SP - 64
EP - 69
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 2
ER -
