Ancestral Differences in Anticancer Treatment Efficacy and Their Underlying Genomic and Molecular Alterations

Mei Luo; Jingwen Yang; Alejandro A. Schäffer; Chengxuan Chen; Yuan Liu; Yamei Chen; Chunru Lin; Lixia Diao; Yong Zang; Yanyan Lou; Huda Salman; Gordon B. Mills; Eytan Ruppin; Leng Han

doi:10.1158/2159-8290.CD-24-0827

Ancestral Differences in Anticancer Treatment Efficacy and Their Underlying Genomic and Molecular Alterations

Mei Luo
, Jingwen Yang
, Alejandro A. Schäffer
, Chengxuan Chen
, Yuan Liu
, Yamei Chen
, Chunru Lin
, Lixia Diao
, Yong Zang
, Yanyan Lou
, Huda Salman
, Gordon B. Mills
, Eytan Ruppin
, Leng Han

Brown Center for Immunotherapy
Indiana University
Department of Biostatistics and Health Data Science
Indiana University Bloomington
Cancer Data Science Laboratory
National Institutes of Health
Department of Molecular and Cellular Oncology
University of Texas MD Anderson Cancer Center
Department of Bioinformatics and Computational Biology
Division of Hematology/Oncology
Mayo Clinic Jacksonville, FL
Division of Hematology-Oncology
Oregon Health and Science University

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

SIGNIFICANCE: Our study charts a global landscape of ancestry-associated differences in therapeutic efficacy, highlighting the importance of considering ancestry in anticancer therapies.

Original language	English
Pages (from-to)	511-529
Number of pages	19
Journal	Cancer discovery
Volume	15
Issue number	3
DOIs	https://doi.org/10.1158/2159-8290.CD-24-0827
State	Published - 3 Mar 2025
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1158/2159-8290.CD-24-0827

Cite this

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title = "Ancestral Differences in Anticancer Treatment Efficacy and Their Underlying Genomic and Molecular Alterations",

abstract = "SIGNIFICANCE: Our study charts a global landscape of ancestry-associated differences in therapeutic efficacy, highlighting the importance of considering ancestry in anticancer therapies.",

author = "Mei Luo and Jingwen Yang and Sch{\"a}ffer, \{Alejandro A.\} and Chengxuan Chen and Yuan Liu and Yamei Chen and Chunru Lin and Lixia Diao and Yong Zang and Yanyan Lou and Huda Salman and Mills, \{Gordon B.\} and Eytan Ruppin and Leng Han",

note = "Publisher Copyright: {\textcopyright}2024 American Association for Cancer Research.",

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T1 - Ancestral Differences in Anticancer Treatment Efficacy and Their Underlying Genomic and Molecular Alterations

AU - Luo, Mei

AU - Yang, Jingwen

AU - Schäffer, Alejandro A.

AU - Chen, Chengxuan

AU - Liu, Yuan

AU - Chen, Yamei

AU - Lin, Chunru

AU - Diao, Lixia

AU - Zang, Yong

AU - Lou, Yanyan

AU - Salman, Huda

AU - Mills, Gordon B.

AU - Ruppin, Eytan

AU - Han, Leng

PY - 2025/3/3

Y1 - 2025/3/3

N2 - SIGNIFICANCE: Our study charts a global landscape of ancestry-associated differences in therapeutic efficacy, highlighting the importance of considering ancestry in anticancer therapies.

AB - SIGNIFICANCE: Our study charts a global landscape of ancestry-associated differences in therapeutic efficacy, highlighting the importance of considering ancestry in anticancer therapies.

UR - https://www.scopus.com/pages/publications/86000674205

U2 - 10.1158/2159-8290.CD-24-0827

DO - 10.1158/2159-8290.CD-24-0827

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C2 - 39601595

AN - SCOPUS:86000674205

SN - 2159-8290

VL - 15

SP - 511

EP - 529

JO - Cancer discovery

JF - Cancer discovery

IS - 3

ER -

Ancestral Differences in Anticancer Treatment Efficacy and Their Underlying Genomic and Molecular Alterations

Abstract

UN SDGs

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