Anaplastic and atypical meningiomas express high levels of Fas and undergo apoptosis in response to Fas ligation

Shira Weisberg, Ely Ashkenazi, Zvi Israel, Moshe Attia, Yigal Shoshan, Felix Umansky, Chaya Brodie

Research output: Contribution to journalArticlepeer-review

Abstract

In this study we characterized the expression of Fas and Fas ligand in different types of meningiomas and examined the effect of Fas ligation on the death of meningioma cells in culture. Using Western blot analysis, we found that extracts derived from anaplastic and atypical meningiomas expressed high levels of Fas, whereas benign meningiomas did not express detectable levels of this protein. All of the meningiomas examined expressed low levels of Fas ligand. Cultures of anaplastic meningiomas also expressed Fas and treatment of these cells with anti-Fas antibody induced cell death. The results of this study indicate that Fas is preferentially expressed in atypical and anaplastic meningiomas and suggest that it is involved in the increased apoptosis observed in these tumors.

Original languageEnglish
Pages (from-to)1193-1197
Number of pages5
JournalAmerican Journal of Pathology
Volume159
Issue number4
DOIs
StatePublished - Oct 2001
Externally publishedYes

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