Analysis of in vivo uterine peristalsis in the non-pregnant female mouse

Ying Zhang, Jingjing Qian, Oren Zaltzhendler, Mustafa Bshara, Ariel J. Jaffa, Dan Grisaru, Enkui Duan, David Elad*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Uterine peristalsis due to spontaneous contractions of the myometrial smooth muscles has important roles in pre-implantation processes of intra-uterine sperm transport to the fertilization site, and then embryo transport to the implantation sites. We developed a new objective methodology to study in vivo uterine peristalsis in female mice during the pro-oestrus phase. The acquisition procedure of the uterine organ is remote without interfering with the organ function. The uniqueness of the new approach is that video images of physiological pattern were converted using image processing and new algorithms to biological time-dependent signals that can be processed with existing algorithms for signal processing. Using this methodology we found that uterine peristalsis in the pro-oestrus mouse is in the range of 0.008-0.029 Hz, which is about one contraction per minute and with fairly symmetric contractions that occasionally propagate caudally. This rate of contractions is similar to that of human uterine peristalsis acquired in vivo, which is important information for a popular animal model.

Original languageEnglish
Article number20180082
JournalInterface Focus
Issue number4
StatePublished - 6 Aug 2019


  • Active contours
  • Fertility
  • Image processing
  • Myometrial smooth muscles
  • Pro-oestrus
  • Uterine contractions


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