Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study

Moran Amit, Yoav Binenbaum, Kanika Sharma, Naomi Ramer, Ilana Ramer, Abib Agbetoba, Brett Miles, Xinjie Yang, Delin Lei, Kristine Bjøerndal, Christian Godballe, Thomas Mücke, Klaus Dietrich Wolff, Dan Fliss, André M. Eckardt, Chiara Copelli, Enrico Sesenna, Frank Palmer, Snehal Patel, Ziv Gil*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Background Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The purpose of this study was to identify independent predictors of outcome and to characterize the patterns of failure. Methods An international retrospective review was conducted of 489 patients with ACC treated between 1985 and 2011 in 9 cancer centers worldwide. Results Five-year overall-survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) were 76%, 80%, and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification, and presence of distant metastases. N classification, age, and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion, and N classification were independent predictors of distant metastases. Conclusion The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastases rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC.

Original languageEnglish
Pages (from-to)998-1004
Number of pages7
JournalHead and Neck
Issue number7
StatePublished - Jul 2014
Externally publishedYes


FundersFunder number
Israel Cancer Research Fund


    • adenoid
    • adenoid cystic
    • adenoid cystic carcinoma
    • head and neck cancer
    • salivary gland tumors


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