Analysis of chromosomal aberrations in large hepatocellular carcinomas by comparative genomic hybridization

Yona Kitay-Cohen, Aliza Amiel*, Yaffa Ashur, Moshe D. Fejgin, Yair Herishanu, Faina Afanasyev, Yonit Bomstein, Michael Lishner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Hepatocellular carcinoma (HCC) is a very common and highly malignant tumor, associated mainly with chronic viral hepatitis, cirrhosis of any cause, aflatoxin exposure and ethanol consumption. The aim of this study was to map genomic aberrations in HCC by a recently developed technique: comparative genomic hybridization (CGH). We applied CGH on 17 liver specimens, of which seven were HCCs. The rest were benign liver tumors, cirrhotic and normal livers, and other liver malignancies. Our study included mainly large tumors (mean size 10.5 cm) unrelated to viral hepatitis or cirrhosis. Our CGH analysis detected genomic imbalances in 42% of HCCs. The common aberrations included DNA gains of 1q, 9p, and 8q and DNA losses of 17p, 13q, 9q, 4q, and 11q. Also, we detected trisomies 8, 9, 18 and 21, which have not been reported previously. Gains and losses of DNA found in this study probably involve oncogenes and tumor suppressor genes that play a role in the puzzle of hepatocarcinogenesis. This study also suggests a possible link between the size of the tumor and the burden of genetic changes.

Original languageEnglish
Pages (from-to)60-64
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume131
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

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