An Update on Medical Therapy for Obesity

Rosane Ness-Abramof, Caroline M. Apovian*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Obesity is a risk factor and exacerbates many chronic conditions, particularly diabetes, but also hypertension, hyperlipidemia, heart disease, stroke, certain cancers, arthritis, and obstructive sleep apnea. Despite increased awareness within the public and healthcare system, there has still been a persistent rise in the prevalence of obesity over the past half-century. Failure to halt this epidemic is related to difficulties in adherence to lifestyle changes, forceful counter-regulatory mechanisms opposing weight loss, and the lack of efficient long-term therapy for obesity. This article summarizes the current medical approach to the treatment of obesity, reviewing strategies for lifestyle modification, available pharmacotherapy both as an adjunct to diet and exercise and to amelioraté ameliorate comorbidities, and an overview of new pharmaceutical agents being developed.

Original languageEnglish
Pages (from-to)145-155
Number of pages11
JournalNutrition in Clinical Practice
Issue number2
StatePublished - Apr 2003
Externally publishedYes


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