An N-terminal amphipathic helix in dengue virus nonstructural protein 4A mediates oligomerization and is essential for replication

Omer Stern, Yu Fu Hung, Olga Valdau, Yakey Yaffe, Eva Harris, Silke Hoffmann, Dieter Willbold, Ella H. Sklan

Research output: Contribution to journalArticlepeer-review

Abstract

Dengue virus (DENV) causes dengue fever, a major health concern worldwide. We identified an amphipathic helix (AH) in the N-terminal region of the viral nonstructural protein 4A (NS4A). Disruption of its amphipathic nature using mutagenesis reduced homo-oligomerization and abolished viral replication. These data emphasize the significance of NS4A in the life cycle of the dengue virus and demarcate it as a target for the design of novel antiviral therapy.

Original languageEnglish
Pages (from-to)4080-4085
Number of pages6
JournalJournal of Virology
Volume87
Issue number7
DOIs
StatePublished - Apr 2013

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