An intracellular antigen that reacts with MO2, a monoclonal antibody to CD14, is expressed by human lymphocytes

Boris Tartakovsky; Mordechai Fried; Margalit Bleiberg; Dan Turner; Michael Hoffman; Israel Yust

doi:10.1016/S0165-2478(02)00199-2

An intracellular antigen that reacts with MO2, a monoclonal antibody to CD14, is expressed by human lymphocytes

Boris Tartakovsky^*, Mordechai Fried, Margalit Bleiberg, Dan Turner, Michael Hoffman, Israel Yust

^*Corresponding author for this work

Tel Aviv Sourasky Medical Center

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

CD14, a lipopolysaccharide (LPS) receptor, is present on the surface membrane of phagocytic leukocytes; it is also present in a soluble form in serum. Recently published results confer to this molecule novel functions that are linked to T-cell activation and to apoptosis. We report here that we have defined and characterized a novel lymphocyte population in human peripheral blood, a population that expresses an intracellular antigen detectable with MO2, a monoclonal antibody directed against the human CD14 molecule. This population is composed primarily of CD8-positive T-cells. We found surprisingly that this novel MO2-positive population of lymphocytes was greatly enhanced in asymptomatic, untreated HIV-positive individuals.

Original language	English
Pages (from-to)	35-40
Number of pages	6
Journal	Immunology Letters
Volume	85
Issue number	1
DOIs	https://doi.org/10.1016/S0165-2478(02)00199-2
State	Published - 2 Jan 2003
Externally published	Yes

Keywords

CD14
HIV
Intracellular antigens
Lymphocytes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0165-2478(02)00199-2

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AU - Tartakovsky, Boris

AU - Fried, Mordechai

AU - Bleiberg, Margalit

AU - Turner, Dan

AU - Hoffman, Michael

AU - Yust, Israel

PY - 2003/1/2

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AB - CD14, a lipopolysaccharide (LPS) receptor, is present on the surface membrane of phagocytic leukocytes; it is also present in a soluble form in serum. Recently published results confer to this molecule novel functions that are linked to T-cell activation and to apoptosis. We report here that we have defined and characterized a novel lymphocyte population in human peripheral blood, a population that expresses an intracellular antigen detectable with MO2, a monoclonal antibody directed against the human CD14 molecule. This population is composed primarily of CD8-positive T-cells. We found surprisingly that this novel MO2-positive population of lymphocytes was greatly enhanced in asymptomatic, untreated HIV-positive individuals.

KW - CD14

KW - HIV

KW - Intracellular antigens

KW - Lymphocytes

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An intracellular antigen that reacts with MO2, a monoclonal antibody to CD14, is expressed by human lymphocytes

Abstract

Keywords

UN SDGs

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