An inflammatory vicious cycle: Fibroblasts and immune cell recruitment in cancer

Yael Raz, Neta Erez*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Cancer-associated fibroblasts (CAFs) have been established as a key component of the crosstalk between tumor cells and their microenvironment. The ability of CAFs to orchestrate tumor-promoting inflammation is central to their role in facilitating tumor growth, invasion, and metastasis. Here we review pathways by which CAFs and their soluble mediators provide multiple complex signals that modulate the recruitment, functional activation status, and retention of immune cells in the tumor microenvironment.

Original languageEnglish
Pages (from-to)1596-1603
Number of pages8
JournalExperimental Cell Research
Volume319
Issue number11
DOIs
StatePublished - 1 Jul 2013

Funding

FundersFunder number
Israel Cancer Research Fund
Seventh Framework Programme276890
Israel Cancer Association20110078
Seventh Framework Programme

    Keywords

    • Cancer
    • Cancer-associated fibroblasts
    • Inflammation
    • Microenvironment

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