TY - JOUR
T1 - An inflammatory vicious cycle
T2 - Fibroblasts and immune cell recruitment in cancer
AU - Raz, Yael
AU - Erez, Neta
N1 - Funding Information:
We thank Dr. Ariel Munitz and Dr. Limor Landsman for critical reading of the manuscript, and Elad Yana for graphic design. NE acknowledges support from the European Union Seventh Framework Programme (FP7/2007–2013) under Grant agreement no. [ 276890 ], the Israel Cancer Association ( #20110078 ), and from the Israel Cancer Research Fund (Research Career Development Award).
PY - 2013/7/1
Y1 - 2013/7/1
N2 - Cancer-associated fibroblasts (CAFs) have been established as a key component of the crosstalk between tumor cells and their microenvironment. The ability of CAFs to orchestrate tumor-promoting inflammation is central to their role in facilitating tumor growth, invasion, and metastasis. Here we review pathways by which CAFs and their soluble mediators provide multiple complex signals that modulate the recruitment, functional activation status, and retention of immune cells in the tumor microenvironment.
AB - Cancer-associated fibroblasts (CAFs) have been established as a key component of the crosstalk between tumor cells and their microenvironment. The ability of CAFs to orchestrate tumor-promoting inflammation is central to their role in facilitating tumor growth, invasion, and metastasis. Here we review pathways by which CAFs and their soluble mediators provide multiple complex signals that modulate the recruitment, functional activation status, and retention of immune cells in the tumor microenvironment.
KW - Cancer
KW - Cancer-associated fibroblasts
KW - Inflammation
KW - Microenvironment
UR - http://www.scopus.com/inward/record.url?scp=84879607721&partnerID=8YFLogxK
U2 - 10.1016/j.yexcr.2013.03.022
DO - 10.1016/j.yexcr.2013.03.022
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AN - SCOPUS:84879607721
SN - 0014-4827
VL - 319
SP - 1596
EP - 1603
JO - Experimental Cell Research
JF - Experimental Cell Research
IS - 11
ER -