An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets

Huiyuan Zhang, Asaf Madi*, Nir Yosef, Norio Chihara, Amit Awasthi, Caroline Pot, Conner Lambden, Amitabh Srivastava, Patrick R. Burkett, Jackson Nyman, Elena Christian, Yasaman Etminan, Annika Lee, Helene Stroh, Junrong Xia, Katarzyna Karwacz, Pratiksha I. Thakore, Nandini Acharya, Alexandra Schnell, Chao WangLionel Apetoh, Orit Rozenblatt-Rosen, Ana C. Anderson, Aviv Regev*, Vijay K. Kuchroo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Zhang et al. construct a transcriptional network for IL-27-mediated Il10 production in CD4 T cells, characterize the function of 16 Il10 regulators, and uncover the role of two transcription factors, Prdm1 and Maf, in driving Il10 production in all T helper cells and in maintaining immune homeostasis in the colon.

Original languageEnglish
Article number108433
JournalCell Reports
Volume33
Issue number8
DOIs
StatePublished - 24 Nov 2020

Funding

FundersFunder number
Broad Institute
Celsius Therapeutics
Astellas Pharma Global Development
Kintai Therapeutics
Compass Therapeutics
Alon Fellowship for Outstanding Young Scientists, Israel Council for Higher Education
Repertoir Immune Medicines
Department of Science and Technology, Ministry of Science and Technology, India
Rubius Therapeutics
National Institutes of Health
Tizona Therapeutics
Sächsische Aufbaubank
Bicara Therapeutics
European Research Council
SABs for Elpiscience Biopharmaceutical Ltd
Howard Hughes Medical Institute
National Institute of Allergy and Infectious DiseasesP01AI129880, P01AI039671, U19AI133524, P01AI073748, P01AI056299, R01AI144166
National Institute of Neurological Disorders and StrokeR01NS030843
DST-SERBCRG/2018/002653
Horizon 2020 Framework Programme677251
Japan Society for the Promotion of Science20H03562
National Cancer InstituteR01CA229400

    Keywords

    • IL-10
    • IL-27
    • Maf
    • Prdm1
    • T helper cells
    • Tr1
    • Treg
    • colitis
    • transcriptional network

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