An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets

Huiyuan Zhang; Asaf Madi; Nir Yosef; Norio Chihara; Amit Awasthi; Caroline Pot; Conner Lambden; Amitabh Srivastava; Patrick R. Burkett; Jackson Nyman; Elena Christian; Yasaman Etminan; Annika Lee; Helene Stroh; Junrong Xia; Katarzyna Karwacz; Pratiksha I. Thakore; Nandini Acharya; Alexandra Schnell; Chao Wang; Lionel Apetoh; Orit Rozenblatt-Rosen; Ana C. Anderson; Aviv Regev; Vijay K. Kuchroo

doi:10.1016/j.celrep.2020.108433

An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets

Huiyuan Zhang, Asaf Madi^*, Nir Yosef, Norio Chihara, Amit Awasthi, Caroline Pot, Conner Lambden, Amitabh Srivastava, Patrick R. Burkett, Jackson Nyman, Elena Christian, Yasaman Etminan, Annika Lee, Helene Stroh, Junrong Xia, Katarzyna Karwacz, Pratiksha I. Thakore, Nandini Acharya, Alexandra Schnell, Chao WangLionel Apetoh, Orit Rozenblatt-Rosen, Ana C. Anderson, Aviv Regev^*, Vijay K. Kuchroo^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

Zhang et al. construct a transcriptional network for IL-27-mediated Il10 production in CD4 T cells, characterize the function of 16 Il10 regulators, and uncover the role of two transcription factors, Prdm1 and Maf, in driving Il10 production in all T helper cells and in maintaining immune homeostasis in the colon.

Original language	English
Article number	108433
Journal	Cell Reports
Volume	33
Issue number	8
DOIs	https://doi.org/10.1016/j.celrep.2020.108433
State	Published - 24 Nov 2020

Keywords

IL-10
IL-27
Maf
Prdm1
T helper cells
Tr1
Treg
colitis
transcriptional network

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10.1016/j.celrep.2020.108433

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Zhang, H., Madi, A., Yosef, N., Chihara, N., Awasthi, A., Pot, C., Lambden, C., Srivastava, A., Burkett, P. R., Nyman, J., Christian, E., Etminan, Y., Lee, A., Stroh, H., Xia, J., Karwacz, K., Thakore, P. I., Acharya, N., Schnell, A., ... Kuchroo, V. K. (2020). An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets. Cell Reports, 33(8), [108433]. https://doi.org/10.1016/j.celrep.2020.108433

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title = "An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets",

abstract = "Zhang et al. construct a transcriptional network for IL-27-mediated Il10 production in CD4 T cells, characterize the function of 16 Il10 regulators, and uncover the role of two transcription factors, Prdm1 and Maf, in driving Il10 production in all T helper cells and in maintaining immune homeostasis in the colon.",

keywords = "IL-10, IL-27, Maf, Prdm1, T helper cells, Tr1, Treg, colitis, transcriptional network",

author = "Huiyuan Zhang and Asaf Madi and Nir Yosef and Norio Chihara and Amit Awasthi and Caroline Pot and Conner Lambden and Amitabh Srivastava and Burkett, {Patrick R.} and Jackson Nyman and Elena Christian and Yasaman Etminan and Annika Lee and Helene Stroh and Junrong Xia and Katarzyna Karwacz and Thakore, {Pratiksha I.} and Nandini Acharya and Alexandra Schnell and Chao Wang and Lionel Apetoh and Orit Rozenblatt-Rosen and Anderson, {Ana C.} and Aviv Regev and Kuchroo, {Vijay K.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = nov,

day = "24",

doi = "10.1016/j.celrep.2020.108433",

language = "אנגלית",

volume = "33",

journal = "Cell Reports",

issn = "2211-1247",

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Zhang, H, Madi, A, Yosef, N, Chihara, N, Awasthi, A, Pot, C, Lambden, C, Srivastava, A, Burkett, PR, Nyman, J, Christian, E, Etminan, Y, Lee, A, Stroh, H, Xia, J, Karwacz, K, Thakore, PI, Acharya, N, Schnell, A, Wang, C, Apetoh, L, Rozenblatt-Rosen, O, Anderson, AC, Regev, A & Kuchroo, VK 2020, 'An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets', Cell Reports, vol. 33, no. 8, 108433. https://doi.org/10.1016/j.celrep.2020.108433

TY - JOUR

T1 - An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets

AU - Zhang, Huiyuan

AU - Madi, Asaf

AU - Yosef, Nir

AU - Chihara, Norio

AU - Awasthi, Amit

AU - Pot, Caroline

AU - Lambden, Conner

AU - Srivastava, Amitabh

AU - Burkett, Patrick R.

AU - Nyman, Jackson

AU - Christian, Elena

AU - Etminan, Yasaman

AU - Lee, Annika

AU - Stroh, Helene

AU - Xia, Junrong

AU - Karwacz, Katarzyna

AU - Thakore, Pratiksha I.

AU - Acharya, Nandini

AU - Schnell, Alexandra

AU - Wang, Chao

AU - Apetoh, Lionel

AU - Rozenblatt-Rosen, Orit

AU - Anderson, Ana C.

AU - Regev, Aviv

AU - Kuchroo, Vijay K.

PY - 2020/11/24

Y1 - 2020/11/24

N2 - Zhang et al. construct a transcriptional network for IL-27-mediated Il10 production in CD4 T cells, characterize the function of 16 Il10 regulators, and uncover the role of two transcription factors, Prdm1 and Maf, in driving Il10 production in all T helper cells and in maintaining immune homeostasis in the colon.

AB - Zhang et al. construct a transcriptional network for IL-27-mediated Il10 production in CD4 T cells, characterize the function of 16 Il10 regulators, and uncover the role of two transcription factors, Prdm1 and Maf, in driving Il10 production in all T helper cells and in maintaining immune homeostasis in the colon.

KW - IL-10

KW - IL-27

KW - Maf

KW - Prdm1

KW - T helper cells

KW - Tr1

KW - Treg

KW - colitis

KW - transcriptional network

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C2 - 33238123

AN - SCOPUS:85096582166

SN - 2211-1247

VL - 33

JO - Cell Reports

JF - Cell Reports

IS - 8

M1 - 108433

ER -

An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets

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