An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets

Huiyuan Zhang, Asaf Madi, Nir Yosef, Norio Chihara, Amit Awasthi, Caroline Pot, Conner Lambden, Amitabh Srivastava, Patrick R. Burkett, Jackson Nyman, Elena Christian, Yasaman Etminan, Annika Lee, Helene Stroh, Junrong Xia, Katarzyna Karwacz, Pratiksha I. Thakore, Nandini Acharya, Alexandra Schnell, Chao WangLionel Apetoh, Orit Rozenblatt-Rosen, Ana C. Anderson, Aviv Regev, Vijay K. Kuchroo

Research output: Contribution to journalArticlepeer-review

Abstract

Zhang et al. construct a transcriptional network for IL-27-mediated Il10 production in CD4 T cells, characterize the function of 16 Il10 regulators, and uncover the role of two transcription factors, Prdm1 and Maf, in driving Il10 production in all T helper cells and in maintaining immune homeostasis in the colon.

Original languageEnglish
Article number108433
JournalCell Reports
Volume33
Issue number8
DOIs
StatePublished - 24 Nov 2020

Keywords

  • IL-10
  • IL-27
  • Maf
  • Prdm1
  • T helper cells
  • Tr1
  • Treg
  • colitis
  • transcriptional network

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